Vti1a - vesicle transport through interaction with t-SNAREs 1A Gene

Rattus norvegicus

Also known as Vti1; DD6A4-2(1)

Gene ID: 65277 | Gene type: protein coding

About Vti1a

Summary

Predicted to enable SNAP receptor activity and SNARE binding activity. Involved in endoplasmic reticulum to Golgi vesicle-mediated transport; synaptic vesicle to endosome fusion; and vesicle fusion with Golgi apparatus. Located in several cellular components, including cytoplasmic vesicle; neuronal cell body; and perinuclear region of cytoplasm. Part of SNARE complex. Orthologous to human VTI1A (vesicle transport through interaction with t-SNAREs 1A). [provided by Alliance of Genome Resources, Apr 2022]

Vti1a Products(1)

mRNA	Protein	Name
NM_023101.1	NP_075589.1	vesicle transport through interaction with t-SNAREs homolog 1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24882364	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum to Golgi vesicle-mediated transport	IDA IDA: Inferred from direct assay	16735505	RGD
involved in synaptic vesicle to endosome fusion	IDA IDA: Inferred from direct assay	17004320	RGD
involved in synaptic vesicle to endosome fusion	IMP IMP: Inferred from mutant phenotype	17004320	RGD
involved in vesicle fusion with Golgi apparatus	IDA IDA: Inferred from direct assay	16735505	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
part of SNARE complex	IDA IDA: Inferred from direct assay	10908612	RGD
located in clathrin-coated vesicle	IDA IDA: Inferred from direct assay	10908612	RGD
is active in hippocampal mossy fiber to CA3 synapse	IDA IDA: Inferred from direct assay	10908612	RGD
located in neuron projection terminus	IDA IDA: Inferred from direct assay	10908612	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	10908612	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	10908612	RGD
is active in synaptic vesicle	IDA IDA: Inferred from direct assay	10908612	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	10908612	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	12067063	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

vesicle transport through interaction with t-SNAREs homolog 1A

SNARE Vti1a-beta protein	vesicle transport v-SNARE protein Vti1-like 2
vti1-rp2

Vti1a Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Vti1a	Q9JI51	Syt11	Mus musculus	Q9R0N3	Pull Down	24882364

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15722	VTI1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20519	Vti1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27028	Vti1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Vti1a	NCBI	NCBI:143187

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