Syt11 - synaptotagmin XI Gene

Mus musculus

Also known as 1500004A13Rik; 3632445O20Rik; 5430404N14Rik; 6530420C11Rik

Gene ID: 229521 | Gene type: protein coding

About Syt11

Summary

Enables several functions, including SNARE binding activity; beta-tubulin binding activity; and identical protein binding activity. Involved in several processes, including learning or memory; negative regulation of cytokine production; and negative regulation of transport. Located in several cellular components, including cytoplasmic vesicle; phagocytic cup; and trans-Golgi network. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human SYT11 (synaptotagmin 11). [provided by Alliance of Genome Resources, Apr 2022]

Syt11 Products(1)

mRNA	Protein	Name
NM_018804.3	NP_061274.2	synaptotagmin-11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables SNARE binding	IPI IPI: Inferred from physical interaction	24882364	MGI
enables beta-tubulin binding	IPI IPI: Inferred from physical interaction	24882364	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	22960622	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	24882364	MGI
enables translation initiation factor binding	IPI IPI: Inferred from physical interaction	24882364	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in autophagy	IMP IMP: Inferred from mutant phenotype	27278822	MGI
involved in calcium ion regulated lysosome exocytosis	IMP IMP: Inferred from mutant phenotype	26450452	MGI
involved in establishment of vesicle localization	IMP IMP: Inferred from mutant phenotype	30808661	MGI
involved in learning	IMP IMP: Inferred from mutant phenotype	30808661	MGI
involved in memory	IMP IMP: Inferred from mutant phenotype	30808661	MGI
involved in negative regulation of cytokine production	IDA IDA: Inferred from direct assay	28686317	MGI
involved in negative regulation of dopamine secretion	IDA IDA: Inferred from direct assay	29311685	MGI
involved in negative regulation of endocytosis	IDA IDA: Inferred from direct assay	29311685	MGI
involved in negative regulation of interleukin-6 production	IDA IDA: Inferred from direct assay	28686317	MGI
involved in negative regulation of interleukin-6 production	IMP IMP: Inferred from mutant phenotype	23303671	MGI
involved in negative regulation of microglial cell activation	IDA IDA: Inferred from direct assay	28686317	MGI
involved in negative regulation of phagocytosis	IDA IDA: Inferred from direct assay	28686317	MGI
involved in negative regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	23303671	MGI
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	28686317	MGI
involved in negative regulation of tumor necrosis factor production	IMP IMP: Inferred from mutant phenotype	23303671	MGI
involved in plasma membrane repair	IMP IMP: Inferred from mutant phenotype	26450452	MGI
involved in positive regulation of protein localization to phagocytic vesicle	IMP IMP: Inferred from mutant phenotype	23303671	MGI
involved in regulation of defense response to bacterium	IMP IMP: Inferred from mutant phenotype	23303671	MGI
involved in regulation of synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	29311685	MGI
involved in regulation of synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	29311685	MGI
involved in response to wounding	IMP IMP: Inferred from mutant phenotype	26450452	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23303671	MGI
located in dendrite	IDA IDA: Inferred from direct assay	30808661	MGI
is active in dopaminergic synapse	IDA IDA: Inferred from direct assay	29311685	MGI
is active in dopaminergic synapse	IMP IMP: Inferred from mutant phenotype	29311685	MGI
located in early phagosome	IDA IDA: Inferred from direct assay	23303671	MGI
located in lysosome	IDA IDA: Inferred from direct assay	23303671	MGI
located in phagocytic cup	IDA IDA: Inferred from direct assay	23303671	MGI
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	25063865	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	11171101	MGI
located in postsynaptic density	IDA IDA: Inferred from direct assay	30808661	MGI
located in recycling endosome	IDA IDA: Inferred from direct assay	23303671	MGI
NOT located in synaptic vesicle	IDA IDA: Inferred from direct assay	30808661	MGI
located in trans-Golgi network	IDA IDA: Inferred from direct assay	28686317	MGI
located in vesicle	IDA IDA: Inferred from direct assay	30808661	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synaptotagmin-11

sytXI

Syt11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Cross	Syt11	Q9R0N3	Vti1a	Rattus norvegicus	Q9JI51	Pull Down	24882364

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14108	SYT11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Syt11	NCBI	NCBI:23208

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