Atp5f1a - ATP synthase F1 subunit alpha Gene

Rattus norvegicus

Also known as Atp5a1

Gene ID: 65262 | Gene type: protein coding

About Atp5f1a

Summary

Enables ADP binding activity; ATP binding activity; and protease binding activity. Contributes to ATP hydrolysis activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to nitric oxide; and response to muscle activity. Located in several cellular components, including cell surface; membrane raft; and mitochondrial inner membrane. Part of mitochondrial proton-transporting ATP Synthase complex, catalytic sector F(1). Used to study non-alcoholic fatty liver disease and pulmonary hypertension. Biomarker of Alzheimer's disease and hypertension. Human ortholog(s) of this gene implicated in combined Oxidative Phosphorylation deficiency 22 and mitochondrial complex V (ATP Synthase) deficiency nuclear type 4. Orthologous to human ATP5F1A (ATP Synthase F1 subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]

Atp5f1a Products(1)

mRNA	Protein	Name
NM_023093.1	NP_075581.1	ATP synthase subunit alpha, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ADP binding	IDA IDA: Inferred from direct assay	2137825	RGD
enables ATP binding	IDA IDA: Inferred from direct assay	2137825	RGD
contributes to ATP hydrolysis activity	IDA IDA: Inferred from direct assay	2894844	RGD
enables protease binding	IPI IPI: Inferred from physical interaction	20850499	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	31511561	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	16215688	RGD
involved in cellular response to nitric oxide	IEP IEP: Inferred from expression pattern	25658244	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	25222487	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	20483212	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	19106112	RGD
located in membrane raft	IDA IDA: Inferred from direct assay	14499952	RGD
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	2894844	RGD
part of proton-transporting ATP synthase complex	IDA IDA: Inferred from direct assay	17575325	RGD
part of proton-transporting ATP synthase complex, catalytic core F(1)	IDA IDA: Inferred from direct assay	1834656	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ATP synthase subunit alpha, mitochondrial

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

mitochondrial H+-ATP synthase alpha subunit

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01202	ATP5F1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18205	Atp5f1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24682	Atp5f1a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Atp5f1a	NCBI	NCBI:498

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