2. Gene
  3. BAD - Bad BCL2-associated agonist of cell death Gene

BAD - Bad BCL2-associated agonist of cell death Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Bad_v1; Bad_v2

Gene ID: 64639 | Gene type: protein coding

About BAD

Summary

Enables 14-3-3 protein binding activity; protein kinase B binding activity; and protein Phosphatase 2B binding activity. Involved in several processes, including cellular response to chromate; positive regulation of cell death; and response to steroid hormone. Located in cytosol and mitochondrion. Used to study several diseases, including Parkinsonism; diabetic neuropathy; gastric ulcer; impotence; and middle cerebral artery infarction. Biomarker of several diseases, including acute kidney failure; artery disease (multiple); brain disease (multiple); obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in endometrial cancer; lung non-small cell carcinoma; and pancreatic Cancer. Orthologous to human BAD (BCL2 associated agonist of cell death). [provided by Alliance of Genome Resources, Apr 2022]

BAD Products(1)

mRNA Protein Name
NM_022698.2 NP_073189.1 bcl2-associated agonist of cell death
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables 14-3-3 protein binding IDA
IDA: Inferred from direct assay
22757651 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
10579309 RGD
enables protein kinase B binding IPI
IPI: Inferred from physical interaction
15120593 RGD
enables protein phosphatase 2B binding IPI
IPI: Inferred from physical interaction
15120593 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to chromate IEP
IEP: Inferred from expression pattern
21262251 RGD
involved in cerebral cortex development IEP
IEP: Inferred from expression pattern
9813151 RGD
involved in positive regulation of granulosa cell apoptotic process IDA
IDA: Inferred from direct assay
9389536 RGD
involved in response to amino acid IEP
IEP: Inferred from expression pattern
17967733 RGD
involved in response to benzene IEP
IEP: Inferred from expression pattern
18093815 RGD
involved in response to calcium ion IEP
IEP: Inferred from expression pattern
17663748 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
17196335 RGD
involved in response to ethanol IEP
IEP: Inferred from expression pattern
17283395 RGD
involved in response to glucocorticoid IEP
IEP: Inferred from expression pattern
15845918 RGD
involved in response to glucose IEP
IEP: Inferred from expression pattern
15596134 RGD
involved in response to hormone IEP
IEP: Inferred from expression pattern
18078455 RGD
involved in response to hydrogen peroxide IEP
IEP: Inferred from expression pattern
17978575 RGD
involved in response to hypoxia IEP
IEP: Inferred from expression pattern
16005992 RGD
involved in response to oleic acid IEP
IEP: Inferred from expression pattern
15627513 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
15625305 RGD
involved in response to progesterone IEP
IEP: Inferred from expression pattern
15941375 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
16011741 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
12099715 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
22513421 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bcl2-associated agonist of cell death

Bcl2-antagonist of cell death

bcl-2 associated death agonist

bcl-2-binding component 6

bcl-xL/Bcl-2-associated death promoter

bcl2 antagonist of cell death

bcl2-associated death promoter

Related Agents

Clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Phase
HY-14266 Dapivirine 99.80% Phase 3
HY-119368 NPB Inhibitor ≥98.0% Phase 3
HY-50868 Bafetinib 99.18% Phase 2
Pre-clinical Phase
Bioactive Molecules (22)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-113427 trans-Vaccenic acid ≥98.0% Unkown
HY-18095 CX-6258 Inhibitor 98.71% Unkown
HY-18095A CX-6258 hydrochloride hydrate Inhibitor 99.23% Unkown
HY-111552 PIM1-IN-1 Inhibitor 99.83% Unkown
HY-18095B CX-6258 hydrochloride Inhibitor 99.03% Unkown
HY-P2468 BAD (103-127) (human) Inhibitor 98.80% Unkown
HY-14266S Dapivirine-d11 / Unkown
HY-P2499 BAD (103-127) (human), FAM-labeled Inhibitor / Unkown
HY-113427S trans-Vaccenic acid-d13 / Unkown
HY-120035 DD1 99.40% Unkown
HY-14266A Dapivirine hydrochloride / Unkown
HY-14266S1 Dapivirine-d4 / Unkown
HY-145844 EGFR-IN-44 / Unkown
HY-146395 HBV-IN-23 / Unkown
HY-147342 β-Benzamide adenine dinucleotide Inhibitor / Unkown
HY-15901 LGB321 Inhibitor / Unkown
HY-15901A LGB321 monohydrochloride Inhibitor / Unkown
HY-168338 CB2 receptor agonist 8 / Unkown
HY-P5324 Bad BH3 (mouse) / Unkown
HY-RS01341 BAD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17318 Bad Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23773 Bad Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens BAD NCBI NCBI:572
Macaca fascicularis BAD NCBI NCBI:102121921
Mus musculus BAD NCBI NCBI:12015