Rab5a - RAB5A, member RAS oncogene family Gene

Rattus norvegicus

Gene ID: 64633 | Gene type: protein coding

About Rab5a

Summary

Enables GDP-dissociation inhibitor binding activity. Involved in several processes, including positive regulation of smooth muscle cell migration; positive regulation of smooth muscle cell proliferation; and regulation of long-term neuronal synaptic plasticity. Located in several cellular components, including cytoplasmic vesicle; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Is anchored component of synaptic vesicle membrane. Orthologous to human RAB5A (RAB5A, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rab5a Products(1)

mRNA	Protein	Name
NM_022692.2	NP_073183.1	ras-related protein Rab-5A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP-dissociation inhibitor binding	IDA IDA: Inferred from direct assay	14709549	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in endocytosis	IMP IMP: Inferred from mutant phenotype	16154939	RGD
involved in endosome organization	IMP IMP: Inferred from mutant phenotype	8043272	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	21125971	RGD
involved in positive regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21125971	RGD
involved in postsynaptic neurotransmitter receptor internalization	IDA IDA: Inferred from direct assay	15629704	RGD
involved in postsynaptic neurotransmitter receptor internalization	IMP IMP: Inferred from mutant phenotype	15629704	RGD
involved in regulation of long-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	18653660	RGD
involved in synaptic vesicle endocytosis	IDA IDA: Inferred from direct assay	20956291	RGD
involved in synaptic vesicle endocytosis	IMP IMP: Inferred from mutant phenotype	20956291	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	8043272	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	8043272	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8043272	RGD
located in early endosome	IDA IDA: Inferred from direct assay	18353411	RGD
located in endosome	IDA IDA: Inferred from direct assay	8043272	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	15629704	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	15629704	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8043272	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12703553	RGD
is active in postsynaptic endocytic zone membrane	IDA IDA: Inferred from direct assay	15629704	RGD
is active in postsynaptic endocytic zone membrane	IMP IMP: Inferred from mutant phenotype	15629704	RGD
is active in presynaptic endosome	IDA IDA: Inferred from direct assay	31074746	RGD
is active in presynaptic endosome	IMP IMP: Inferred from mutant phenotype	31074746	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	14709549	RGD
located in recycling endosome	IDA IDA: Inferred from direct assay	10468577	RGD
located in somatodendritic compartment	IDA IDA: Inferred from direct assay	8043272	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	8043272	RGD
is active in synaptic vesicle membrane	EXP EXP: Inferred from Experiment	20926670	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	20926670	RGD
located in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	20926670	RGD
is active in synaptic vesicle membrane	IMP IMP: Inferred from mutant phenotype	20926670	RGD
located in zymogen granule membrane	IDA IDA: Inferred from direct assay	8166729	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rab-5A

small GTP-binding protein rab5

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11571	RAB5A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21715	Rab5a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28233	Rab5a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rab5a	NCBI	NCBI:5868

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