2. Gene
  3. Nphs1 - NPHS1 adhesion molecule, nephrin Gene

Nphs1 - NPHS1 adhesion molecule, nephrin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 64563 | Gene type: protein coding

About Nphs1

Summary

Enables alpha-actinin binding activity; protein domain specific binding activity; and spectrin binding activity. Predicted to be involved in several processes, including myoblast fusion; regulation of excretion; and skeletal muscle tissue development. Predicted to act upstream of or within JNK cascade; cell adhesion; and positive regulation of actin filament polymerization. Located in several cellular components, including basement membrane; membrane raft; and slit diaphragm. Part of protein-containing complex. Biomarker of end stage renal disease; kidney failure; membranous glomerulonephritis; and nephrotic syndrome. Human ortholog(s) of this gene implicated in nephrotic syndrome type 1. Orthologous to human NPHS1 (NPHS1 adhesion molecule, nephrin). [provided by Alliance of Genome Resources, Apr 2022]

Nphs1 Products(1)

mRNA Protein Name
NM_022628.1 NP_072150.1 nephrin precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables alpha-actinin binding IPI
IPI: Inferred from physical interaction
15331416 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15994232 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
15331416 RGD
enables spectrin binding IPI
IPI: Inferred from physical interaction
15331416 RGD
Cellular Component GO Annotation Evidence Reference Source
located in basement membrane IDA
IDA: Inferred from direct assay
21876538 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
20534871 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15331416 RGD
located in slit diaphragm IDA
IDA: Inferred from direct assay
15994232 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nephrin

NPHS1 nephrin

nephrosis 1 homolog, nephrin

nephrosis 1, congenital, Finnish type (nephrin)

renal glomerulus-specific cell adhesion receptor

Nphs1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Nphs1 Q9R044 Sirpa Rattus norvegicus P97710
Anti Bait CoIP
22747997
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS16221 Nphs1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS09486 NPHS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS16347 Nphs1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Nphs1 NCBI NCBI:4868