Fzd2 - frizzled class receptor 2 Gene

Rattus norvegicus

Also known as Fz-10; Fzd10

Gene ID: 64512 | Gene type: protein coding

About Fzd2

Summary

Enables Wnt-activated receptor activity; identical protein binding activity; and protein heterodimerization activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; Wnt signaling pathway; and cellular response to vitamin D. Located in plasma membrane. Biomarker of myocardial infarction. Human ortholog(s) of this gene implicated in omodysplasia 2. Orthologous to human FZD2 (Frizzled class receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Fzd2 Products(1)

mRNA	Protein	Name
NM_172035.2	NP_742032.2	frizzled-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Wnt receptor activity	IDA IDA: Inferred from direct assay	12471263	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	14688793	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	14688793	RGD
enables protein heterodimerization activity	IPI IPI: Inferred from physical interaction	14688793	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger	IDA IDA: Inferred from direct assay	12471263	RGD
involved in Wnt signaling pathway, calcium modulating pathway	IDA IDA: Inferred from direct assay	12471263	RGD
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	24080158	RGD
involved in cellular response to growth factor stimulus	IEP IEP: Inferred from expression pattern	1334084	RGD
involved in cellular response to peptide hormone stimulus	IEP IEP: Inferred from expression pattern	1334084	RGD
involved in cellular response to vitamin D	IEP IEP: Inferred from expression pattern	1334084	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	12471263	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	14688793	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

frizzled-2

Drosophila polarity gene (frizzled) homologue	Drosophila polarity gene homolog 2
frizzled family receptor 2	fz-2
rFz2

Fzd2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fzd2	Q08464	Dlg4	Mus musculus	Q62108	Imaging	12067714
Intra	Fzd2	Q08464	Fzd2	Rattus norvegicus	Q08464	Beta Galactosidase	14688793
Intra	Fzd2	Q08464	Fzd2	Rattus norvegicus	Q08464	BRET	14688793
Intra	Fzd2	Q08464	Fzd1	Rattus norvegicus	Q08463	Beta Galactosidase	14688793
Intra	Fzd2	Q08464	Fzd1	Rattus norvegicus	Q08463	BRET	14688793

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05178	FZD2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18359	Fzd2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24838	Fzd2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fzd2	NCBI	NCBI:2535
Mus musculus	Fzd2	NCBI	NCBI:57265

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