Isl1 - ISL LIM homeobox 1 Gene

Rattus norvegicus

Also known as Isl-1; isl-1=homeobox

Gene ID: 64444 | Gene type: protein coding

About Isl1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and Estrogen receptor binding activity. Involved in several processes, including cellular response to glucocorticoid stimulus; negative regulation of intracellular Estrogen receptor signaling pathway; and positive regulation of Insulin secretion. Located in nucleus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus and type 2 diabetes mellitus. Orthologous to human ISL1 (ISL LIM homeobox 1). [provided by Alliance of Genome Resources, Apr 2022]

Isl1 Products(1)

mRNA	Protein	Name
NM_017339.3	NP_059035.3	insulin gene enhancer protein ISL-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19619559	RGD
enables LIM domain binding	IMP IMP: Inferred from mutant phenotype	26260513	RGD
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19619559	RGD
enables core promoter sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11043578	RGD
enables nuclear estrogen receptor binding	IDA IDA: Inferred from direct assay	11043578	RGD
enables nuclear receptor binding	IDA IDA: Inferred from direct assay	11043578	RGD
enables nuclear receptor binding	IPI IPI: Inferred from physical interaction	11043578	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	9315627	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	1691825	RGD
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	18539116	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in axon regeneration	IEP IEP: Inferred from expression pattern	10363827	RGD
involved in cellular response to glucocorticoid stimulus	IEP IEP: Inferred from expression pattern	19619559	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	23270756	RGD
involved in negative regulation of epithelial cell proliferation	IMP IMP: Inferred from mutant phenotype	23270756	RGD
involved in negative regulation of intracellular estrogen receptor signaling pathway	IDA IDA: Inferred from direct assay	11043578	RGD
involved in negative regulation of mesenchymal cell proliferation	IMP IMP: Inferred from mutant phenotype	23270756	RGD
involved in negative regulation of protein-containing complex assembly	IDA IDA: Inferred from direct assay	11043578	RGD
involved in positive regulation of calcium ion import	IMP IMP: Inferred from mutant phenotype	29678908	RGD
involved in positive regulation of epithelial to mesenchymal transition	IMP IMP: Inferred from mutant phenotype	23270756	RGD
involved in positive regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	11978636	RGD
involved in positive regulation of peptidyl-serine phosphorylation	IMP IMP: Inferred from mutant phenotype	29678908	RGD
involved in positive regulation of smoothened signaling pathway	IDA IDA: Inferred from direct assay	32544883	RGD
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	16613990	RGD
involved in positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	18539116	RGD
involved in positive regulation of type B pancreatic cell apoptotic process	IMP IMP: Inferred from mutant phenotype	30341898	RGD
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7759514	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	30341898	RGD
located in nucleus	IDA IDA: Inferred from direct assay	11043578	RGD
part of transcription regulator complex	IDA IDA: Inferred from direct assay	18539116	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin gene enhancer protein ISL-1

ISL1 transcription factor LIM/homeodomain (islet-1)	ISL1 transcription factor, LIM/homeodomain 1
isl-1 homeobox	islet-1

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06931	ISL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18481	Isl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24962	Isl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Isl1	NCBI	NCBI:3670

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