2. Gene
  3. Calr - calreticulin Gene

Calr - calreticulin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 64202 | Gene type: protein coding

About Calr

Summary

Enables several functions, including hormone binding activity; metal ion binding activity; and peptide binding activity. Involved in several processes, including cellular response to lithium ion; response to estradiol; and response to testosterone. Located in several cellular components, including acrosomal vesicle; endoplasmic reticulum; and perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of vitamin B12 deficiency. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; pancreatic ductal adenocarcinoma; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Apr 2022]

Calr Products(1)

mRNA Protein Name
NM_022399.2 NP_071794.1 calreticulin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables calcium ion binding IDA
IDA: Inferred from direct assay
8500729 RGD
enables hormone binding IPI
IPI: Inferred from physical interaction
12603316 RGD
enables iron ion binding IDA
IDA: Inferred from direct assay
8500729 RGD
enables mRNA binding IDA
IDA: Inferred from direct assay
14726956 RGD
enables peptide binding IDA
IDA: Inferred from direct assay
10833321 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
22665516 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cardiac muscle cell differentiation IEP
IEP: Inferred from expression pattern
9011638 RGD
involved in cellular response to electrical stimulus IEP
IEP: Inferred from expression pattern
28428881 RGD
involved in cellular response to lithium ion IEP
IEP: Inferred from expression pattern
16236328 RGD
involved in cellular response to virus IEP
IEP: Inferred from expression pattern
31399043 RGD
involved in response to biphenyl IEP
IEP: Inferred from expression pattern
11452518 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
16339744 RGD
involved in response to glycoside IEP
IEP: Inferred from expression pattern
28428881 RGD
involved in response to peptide IEP
IEP: Inferred from expression pattern
10833321 RGD
involved in response to testosterone IEP
IEP: Inferred from expression pattern
9751517 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
11032977 RGD
involved in spermatogenesis IEP
IEP: Inferred from expression pattern
8453984 RGD
Cellular Component GO Annotation Evidence Reference Source
located in acrosomal vesicle IDA
IDA: Inferred from direct assay
8453984 RGD
located in cell surface IDA
IDA: Inferred from direct assay
11891802 RGD
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
12782144 RGD
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
33239744 RGD
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18385140 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12782144 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
33239744 RGD
located in nuclear envelope IDA
IDA: Inferred from direct assay
20607274 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
8600158 RGD
is active in postsynapse IDA
IDA: Inferred from direct assay
33239744 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
12401114 RGD
located in sarcoplasmic reticulum IDA
IDA: Inferred from direct assay
8600158 RGD
located in smooth endoplasmic reticulum IDA
IDA: Inferred from direct assay
22665516 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

calreticulin

CABP3

CALBP

CRP55

ERp60

HACBP

calcium-binding protein 3

calregulin

endoplasmic reticulum resident protein 60

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01847 CALR Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS01848 CALR3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17947 Calr Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20371 Calr3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24418 Calr Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26881 Calr3 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Calr NCBI NCBI:811
Mus musculus Calr NCBI NCBI:12317
Susscrofa domestica Calr NCBI