2. Gene
  3. Mre11 - MRE11 homolog, double strand break repair nuclease Gene

Mre11 - MRE11 homolog, double strand break repair nuclease Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Mre11a

Gene ID: 64046 | Gene type: protein coding

About Mre11

Summary

Predicted to enable identical protein binding activity; nuclease activity; and protein C-terminus binding activity. Predicted to contribute to DNA binding activity and DNA helicase activity. Involved in heart development and negative regulation of viral entry into host cell. Located in chromatin; nuclear lumen; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in breast carcinoma; endometrial cancer; stomach carcinoma; and urinary bladder Cancer. Orthologous to human MRE11 (MRE11 homolog, double strand break repair nuclease). [provided by Alliance of Genome Resources, Apr 2022]

Mre11 Products(2)

mRNA Protein Name
NM_022279.1 NP_071615.1 double-strand break repair protein MRE11
NM_022279.1 NP_071615.1 double-strand break repair protein MRE11
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
18212738 RGD
Biological Process GO Annotation Evidence Reference Source
involved in heart development IEP
IEP: Inferred from expression pattern
10908350 RGD
involved in negative regulation of viral entry into host cell IMP
IMP: Inferred from mutant phenotype
22850678 RGD
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
10855503 RGD
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
10855503 RGD
located in nucleoplasm IDA
IDA: Inferred from direct assay
16706843 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
18212738 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

double-strand break repair protein MRE11

MRE11 homolog 1

MRE11 homolog A, double strand break repair nuclease

MRE11 homolog, double strand break repair nuclease A

MRE11 meiotic recombination 11 homolog A

double-strand break repair protein MRE11A

meiotic recombination 11 homolog 1

meiotic r

Related Agents

Pre-clinical Phase
Bioactive Molecules (10)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-117693 (E/Z)-Mirin Inhibitor 99.22% Unkown
HY-116770 PFM01 Inhibitor 99.91% Unkown
HY-19959 Mirin 99.63% Unkown
HY-120951 PFM39 Inhibitor 99.01% Unkown
HY-148078 PFM03 Inhibitor 99.86% Unkown
HY-170844 MU147 Inhibitor 99.35% Unkown
HY-170845 MU1409 Inhibitor 98.52% Unkown
HY-RS08643 MRE11 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-149972 Antitumor agent-96 Inducer / Unkown
HY-RS24170 Mre11 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Mre11 NCBI NCBI:4361