2. Gene
  3. Glrx - glutaredoxin Gene

Glrx - glutaredoxin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Grx; Glrx1

Gene ID: 64045 | Gene type: protein coding

About Glrx

Summary

Enables glutathione disulfide oxidoreductase activity. Involved in several processes, including cellular response to estradiol stimulus; positive regulation of secretion by cell; and regulation of signal transduction. Located in several cellular components, including dendrite; mitochondrial intermembrane space; and neuronal cell body. Biomarker of obesity and transient cerebral ischemia. Orthologous to human GLRX (glutaredoxin). [provided by Alliance of Genome Resources, Apr 2022]

Glrx Products(1)

mRNA Protein Name
NM_022278.1 NP_071614.1 glutaredoxin-1
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables glutathione disulfide oxidoreductase activity IDA
IDA: Inferred from direct assay
12135599 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to estradiol stimulus IDA
IDA: Inferred from direct assay
16549430 RGD
involved in cellular response to glucose stimulus IEP
IEP: Inferred from expression pattern
17324929 RGD
involved in negative regulation of hydrogen peroxide-mediated programmed cell death IMP
IMP: Inferred from mutant phenotype
19938943 RGD
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: Inferred from mutant phenotype
16893901 RGD
involved in ovulation cycle process IEP
IEP: Inferred from expression pattern
15956334 RGD
involved in positive regulation of cell adhesion molecule production IMP
IMP: Inferred from mutant phenotype
17324929 RGD
involved in positive regulation of exocytosis IMP
IMP: Inferred from mutant phenotype
19299446 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
19299446 RGD
involved in positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: Inferred from mutant phenotype
19938943 RGD
involved in response to ischemia IEP
IEP: Inferred from expression pattern
19938943 RGD
Cellular Component GO Annotation Evidence Reference Source
located in dendrite IDA
IDA: Inferred from direct assay
20620191 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
20620191 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutaredoxin-1

TTase-1

glutaredoxin (thioltransferase)

glutaredoxin 1 (thioltransferase)

thioltransferase-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05496 GLRX Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05497 GLRX2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05498 GLRX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS05499 GLRX5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18939 Glrx Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22529 Glrx5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25429 Glrx Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29049 Glrx5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glrx NCBI NCBI:2745