Nmu - neuromedin U Gene

Rattus norvegicus

Gene ID: 63887 | Gene type: protein coding

About Nmu

Summary

Enables type 1 neuromedin U receptor binding activity and type 2 neuromedin U receptor binding activity. Involved in several processes, including energy homeostasis; negative regulation of digestive system process; and positive regulation of cell communication. Acts upstream of or within neuropeptide signaling pathway. Located in terminal bouton. Used to study obesity. Human ortholog(s) of this gene implicated in obesity. Orthologous to human NMU (neuromedin U). [provided by Alliance of Genome Resources, Apr 2022]

Nmu Products(1)

mRNA	Protein	Name
NM_022239.3	NP_071575.1	neuromedin-U precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuromedin U receptor binding	IDA IDA: Inferred from direct assay	15635449	RGD
enables type 1 neuromedin U receptor binding	IDA IDA: Inferred from direct assay	28874765	RGD
enables type 2 neuromedin U receptor binding	IDA IDA: Inferred from direct assay	28874765	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in eating behavior	IDA IDA: Inferred from direct assay	10894543	RGD
involved in energy homeostasis	IDA IDA: Inferred from direct assay	10894543	RGD
involved in gastric acid secretion	IMP IMP: Inferred from mutant phenotype	12584108	RGD
involved in negative regulation of eating behavior	IDA IDA: Inferred from direct assay	10894543	RGD
involved in negative regulation of feeding behavior	IDA IDA: Inferred from direct assay	20233222	RGD
involved in negative regulation of gastric acid secretion	IDA IDA: Inferred from direct assay	12584108	RGD
involved in negative regulation of gastric emptying	IDA IDA: Inferred from direct assay	12584108	RGD
acts upstream of or within neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	15635449	RGD
involved in photoperiodism	IEP IEP: Inferred from expression pattern	17726140	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	28874765	RGD
involved in positive regulation of heart rate	IDA IDA: Inferred from direct assay	11853869	RGD
involved in positive regulation of heat generation	IDA IDA: Inferred from direct assay	11027662	RGD
involved in positive regulation of hormone secretion	IMP IMP: Inferred from mutant phenotype	17726140	RGD
involved in positive regulation of prolactin secretion	IDA IDA: Inferred from direct assay	28874765	RGD
involved in positive regulation of sensory perception of pain	IDA IDA: Inferred from direct assay	12890516	RGD
involved in positive regulation of smooth muscle contraction	IDA IDA: Inferred from direct assay	3178840	RGD
involved in positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	16474416	RGD
involved in positive regulation of stomach fundus smooth muscle contraction	IDA IDA: Inferred from direct assay	2055247	RGD
involved in positive regulation of synaptic transmission	IMP IMP: Inferred from mutant phenotype	15297576	RGD
involved in positive regulation of systemic arterial blood pressure	IDA IDA: Inferred from direct assay	11853869	RGD
involved in regulation of circadian sleep/wake cycle, sleep	IDA IDA: Inferred from direct assay	20233222	RGD
involved in regulation of grooming behavior	IDA IDA: Inferred from direct assay	12399416	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in terminal bouton	IDA IDA: Inferred from direct assay	15297576	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

neuromedin-U

neuromedin U precursor-related peptide/neuromedin U preproprotein

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-34758	N-Nitroso-N-methylurea		≥98.0%	Unkown
HY-P1238A	Neuromedin U, rat TFA		99.69%	Unkown
HY-N6629	3'-Methoxyflavonol		99.92%	Unkown
HY-P1238	Neuromedin U, rat		/	Unkown
HY-P5084	Neuromedin S (human)		/	Unkown
HY-RS09391	NMU Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17526	Nmu Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23983	Nmu Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nmu	NCBI	NCBI:10874

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