Actn4 - actinin alpha 4 Gene

Mus musculus

Gene ID: 60595 | Gene type: protein coding

About Actn4

Summary

Enables actin filament binding activity. Involved in several processes, including bicellular tight junction assembly; positive regulation of pinocytosis; and protein localization to bicellular tight junction. Located in several cellular components, including Z disc; cytoskeleton; and pseudopodium. Is expressed in early conceptus and heart. Used to study focal segmental glomerulosclerosis 1. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 1. Orthologous to human ACTN4 (actinin alpha 4). [provided by Alliance of Genome Resources, Apr 2022]

Actn4 Products(4)

mRNA	Protein	Name
NM_001360548.1	NP_001347477.1	alpha-actinin-4 isoform 2
NM_001360549.1	NP_001347478.1	alpha-actinin-4 isoform 3
NM_001360550.1	NP_001347479.1	alpha-actinin-4 isoform 4
NM_021895.3	NP_068695.1	alpha-actinin-4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin filament binding	IDA IDA: Inferred from direct assay	15465019	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12960352	MGI
enables structural constituent of cytoskeleton	IMP IMP: Inferred from mutant phenotype	12782671	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin filament bundle assembly	IDA IDA: Inferred from direct assay	15841212	MGI
involved in bicellular tight junction assembly	IMP IMP: Inferred from mutant phenotype	18332111	MGI
acts upstream of or within gene expression	IMP IMP: Inferred from mutant phenotype	16501493	MGI
involved in glomerulus development	IDA IDA: Inferred from direct assay	12782671	MGI
involved in podocyte cell migration	IMP IMP: Inferred from mutant phenotype	16837921	MGI
involved in positive regulation of pinocytosis	IMP IMP: Inferred from mutant phenotype	10954430	MGI
involved in protein localization to bicellular tight junction	IMP IMP: Inferred from mutant phenotype	18332111	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	20215401	MGI
located in cell-cell junction	IDA IDA: Inferred from direct assay	18332111	MGI
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	16837921	MGI
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	12960352	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	12960352	MGI
located in focal adhesion	IDA IDA: Inferred from direct assay	16837921	MGI
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	33228246	MGI
located in pseudopodium	IDA IDA: Inferred from direct assay	15633123	MGI
colocalizes with stress fiber	IDA IDA: Inferred from direct assay	23890175	MGI
located in stress fiber	IDA IDA: Inferred from direct assay	15841212	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

alpha-actinin-4

F-actin cross-linking protein

non-muscle alpha-actinin 4

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00226	ACTN4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20360	Actn4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26869	Actn4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Actn4	NCBI	NCBI:81

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