TRPV4 - transient receptor potential cation channel subfamily V member 4 Gene

Homo sapiens

Also known as SMAL; VRL2; BCYM3; CMT2C; SPSMA; TRP12; VROAC; HMSN2C; OTRPC4; SSQTL1

Gene ID: 59341 | Gene type: protein coding

About TRPV4

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,783,087-109,833,398 (from NCBI)

This gene has 11 transcripts (splice variants), 209 orthologues, 5 paralogues and is associated with 23 phenotypes. Broad expression in kidney (RPKM 5.7), salivary gland (RPKM 3.0) and 14 other tissues.

Summary

This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]

TRPV4 Products(5)

mRNA	Protein	Name
NM_001177428.1	NP_001170899.1	transient receptor potential cation channel subfamily V member 4 isoform e
NM_001177431.1	NP_001170902.1	transient receptor potential cation channel subfamily V member 4 isoform d
NM_001177433.1	NP_001170904.1	transient receptor potential cation channel subfamily V member 4 isoform c
NM_021625.5	NP_067638.3	transient receptor potential cation channel subfamily V member 4 isoform a
NM_147204.2	NP_671737.1	transient receptor potential cation channel subfamily V member 4 isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium channel activity	IDA IDA: Inferred from direct assay	18458941	GOA
enables calmodulin binding	IMP IMP: Inferred from mutant phenotype	12724311	GOA
enables identical protein binding	IPI IPI: Inferred from physical interaction	26146187	GOA
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	12724311	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16293632	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	12538589	GOA
enables stretch-activated, monoatomic cation-selective, calcium channel activity	IMP IMP: Inferred from mutant phenotype	23136043	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel endothelial cell delamination	IMP IMP: Inferred from mutant phenotype	23136043	GOA
involved in calcium ion import into cytosol	IDA IDA: Inferred from direct assay	29899501	GOA
involved in calcium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	23136043	GOA
involved in calcium ion transport	IDA IDA: Inferred from direct assay	18458941	GOA
involved in cartilage development involved in endochondral bone morphogenesis	IMP IMP: Inferred from mutant phenotype	26249260	GOA
involved in cellular hypotonic response	IMP IMP: Inferred from mutant phenotype	23136043	GOA
involved in intracellular calcium ion homeostasis	IDA IDA: Inferred from direct assay	12724311	GOA
involved in multicellular organismal-level water homeostasis	IMP IMP: Inferred from mutant phenotype	23136043	GOA
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	18458941	GOA
involved in positive regulation of vascular permeability	IMP IMP: Inferred from mutant phenotype	23136043	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	15753126	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPV4 Protein Structure

Ank

Ion_trans

0
200
400
600
800
871 a.a.

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily V member 4

OSM9-like transient receptor potential channel 4

TRPV4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	TRPV4	Q9HBA0	RAN	Homo sapiens	P62826	Pull Down	24855949
Intra	TRPV4	Q9HBA0	TRPV4	Homo sapiens	Q9HBA0	Anti Tag CoIP	26146187
Intra	TRPV4	Q9HBA0	HIF1AN	Homo sapiens	Q9NWT6	Enzymatic Study	21251231
Intra	TRPV4	Q9HBA0	TRPV4	Homo sapiens	Q9HBA0	FRET	26146187
Intra	TRPV4	Q9HBA0	Agtr1	Rattus norvegicus	P25095	Anti Tag CoIP	32493776

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Metatropic Dysplasia

Metatropic Dwarfism	MTD
Metatropic Dysplasia Type 1	Metatropic Dysplasia, Nonlethal Dominant

Hereditary Motor And Sensory Neuropathy, Type Iic

CMT2C	Charcot-Marie-Tooth Disease Axonal Type 2c
HMSN2C	Hmsn Iic
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2c	Charcot-Marie-Tooth Neuropathy Type 2c
Hereditary Motor And Sensory Neuropathy Type Iic	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2c
Charcot-Marie-Tooth Neuropathy, Type 2c	Autosomal Cominant Axonal Charcot-Marie-Tooth Disease Type 2c
Charcot-Marie-Tooth Disease 2c	Charcot-Marie-Tooth Disease Axonal Autosomal Dominant 2c
Charcot-Marie-Tooth Disease, Type 2c

Scapuloperoneal Spinal Muscular Atrophy

SPSMA	Amyotrophy, Neurogenic Scapuloperoneal, New England Type
Neurogenic Scapuloperoneal Amyotrophy, New England Type	Scapuloperoneal Neuronopathy
Spinal Muscular Atrophy, Scapuloperoneal	Amyotrophy Neurogenic Scapuloperoneal New England Type
Muscular Atrophy, Spinal	Scapuloperoneal Form Of Spinal Muscular Atrophy

Spondylometaphyseal Dysplasia, Kozlowski Type

Spondylometaphyseal Dysplasia Kozlowski Type	Jequier Kozlowski Skeletal Dysplasia
Smd Kozlowski Type	SMDK
Dysmorphism Arthrogryposis Skeletal Maturation Advanced	Jequier-Kozlowski Syndrome
Skeletal Dysplasia Jequier-Kozlowski Type	Smd, Kozlowski Type

Neuronopathy, Distal Hereditary Motor, Type Viii

Autosomal Dominant Congenital Benign Spinal Muscular Atrophy	HMN8
Dhmn8	Neuropathy, Distal Hereditary Motor, Type Viii
Distal Hereditary Motor Neuronopathy Type 8	Autosomal Dominant Benign Distal Spinal Muscular Atrophy
Congenital Benign Spinal Muscular Atrophy With Contractures	Congenital Nonprogressive Spinal Muscular Atrophy
Spinal Muscular Atrophy, Distal, Congenital Nonprogressive	Spinal Muscular Atrophy, Congenital Benign, With Contractures
Distal Hereditary Motor Neuropathy Type Viii	Neuronopathy, Distal Hereditary Motor, 8
Distal Spinal Muscular Atrophy, Congenital Non-Progressive	Spinal Muscular Atrophy Congenital Benign With Contractures

Parastremmatic Dwarfism

Parastremmatic Dysplasia	PSTD
Dwarfism, Parastremmatic

Digital Arthropathy-Brachydactyly, Familial

Familial Digital Arthropathy-Brachydactyly

FDAB

Brachyolmia Type 3

Brachyrachia	Autosomal Dominant Brachyolmia
BCYM3	Brachyolmia, Autosomal Dominant
Brachyolmia Autosomal Dominant	Brachyolmia 3
Brachyolmia, Type 3

Spondyloepiphyseal Dysplasia, Maroteaux Type

Spondyloepiphyseal Dysplasia Maroteaux Type	Pseudo-Morquio Syndrome Type 2
Sed, Maroteaux Type	Brachyolmia Type 2
Pseudo-Morquio Syndrome, Type 2	Spondyloepiphyseal Dysplasia Of Maroteaux
Brachyolmia Maroteaux Type	SEDM
Sed Maroteaux Type	Dysplasia, Spondyloepiphyseal, Maroteaux Type

Avascular Necrosis Of Femoral Head, Primary, 2

ANFH2

Avascular Necrosis Of The Femoral Head, Primary 2

Sodium Serum Level Quantitative Trait Locus 1

Sodium Serum Level Qtl 1

SSQTL1

Trpv4-Related Bone Disorder

Skeletal Dysplasia And Progressive Central Nervous System Degeneration, Lethal

Familial Avascular Necrosis Of The Femoral Head

Familial Osteonecrosis Of The Femoral Head	Primary Avascular Necrosis Of The Femoral Head
Familial Avascular Necrosis Of Femoral Head	Avascular Necrosis Of Femoral Head, Primary

Clubfoot

Congenital Talipes Equinovarus	Congenital Clubfoot
Congenital Equinovarus	Equinovarus Deformity Of Foot
Club Foot

Neuromuscular Disease

Neuromuscular Diseases	Neuromuscular Disorders
Neuromuscular Disorder

Talipes Equinovarus

Congenital Equinovarus	Congenital Talipes Equinovarus
Equinovarus	Congenital Varus Clubfoot

Clubfoot, Congenital, With Or Without Deficiency Of Long Bones And/Or Mirror-Image Polydactyly

CCF	Familial Clubfoot Due To 5q31 Microdeletion
Familial Clubfoot Due To Pitx1 Point Mutation	Hereditary Clubfoot Due To Pitx1 Point Mutation
Hereditary Clubfoot Due To 5q31 Microdeletion	Talipes Equinovarus
Tev	Clubfoot, Congenital, With/Without Deficiency Of Long Bones And/Or Mirror-Image Polydactyly

Osteochondrodysplasia

Skeletal Dysplasia	Chondrodystrophy
Congenital Anomaly Of Cartilage	Osteochondrodysplasias
Cartilage Development Disorder	Osteochondrodysplasia Syndrome
Dysplasia, Skeletal	Mucopolysaccharidosis Iv

Primary Bone Dysplasia

Primary Osteodysplasia

Primary Skeletal Dysplasia

Charcot-Marie-Tooth Disease

Cmt	Hmsn
Hereditary Motor And Sensory Neuropathy	Pma
Cmt - Charcot-Marie-Tooth Disease	Charcot Marie Tooth Disease
Charcot-Marie-Tooth Hereditary Neuropathy	Charcot-Marie-Tooth Syndrome
Peroneal Muscular Atrophy	Hereditary Motor And Sensory Neuropathies

Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome	BWS
Exomphalos-Macroglossia-Gigantism Syndrome	Emg Syndrome
Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation	Emg Abnormality
Wbs	Exomphalos Macroglossia Gigantism Syndrome
Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation	Macroglossia Exomphalos Gigantism

Brachyolmia

Brachyrachia

Progressive Muscular Atrophy

Progressive Spinal Muscular Atrophy	Pure Progressive Muscular Atrophy
Pma	Hereditary Spinal Muscle Atrophy
Pma - [Progressive Muscular Atrophy]	Progressive Muscle Atrophy
Progressive Spinal Muscle Atrophy	Duchenne-Aran Atrophy
Duchenne-Aran Muscle Atrophy	Hereditary Sma - [Spinal Muscle Atrophy]

Genetic Motor Neuron Disease

Genetic Anterior Horn Cell Disease

Connective Tissue Disease

Connective Tissue Diseases	Connective Tissue Disorder
Abnormality Of Connective Tissue	Disorder Of Connective Tissue
Connective Tissue Disorders

Arthropathy

Ankylosis Of Ankle And Foot Joint	Ankylosis Of Forearm Joint
Ankylosis Of Hand Joint	Ankylosis Of Joint Of Ankle And/Or Foot
Ankylosis Of Joint Of Forearm	Ankylosis Of Joint Of Hand
Ankylosis Of Joint Of Lower Leg	Ankylosis Of Joint Of Multiple Sites
Ankylosis Of Joint Of Pelvic Region And Thigh	Ankylosis Of Joint Of Shoulder Region
Ankylosis Of Joint Of Upper Arm	Ankylosis Of Lower Leg Joint
Ankylosis Of Multiple Joints	Ankylosis Of Upper Arm Joint
Infectious Arthropathy	Joint Ankylosis Of The Ankle And Foot
Joint Ankylosis Of The Ankle And/Or Foot	Joint Ankylosis Of The Forearm
Joint Ankylosis Of The Hand	Joint Ankylosis Of The Lower Leg
Joint Ankylosis Of The Pelvic Region And Thigh	Joint Ankylosis Of The Shoulder Region
Joint Ankylosis Of The Upper Arm	Joint Diseases
Joint Disease	Arthropathy Associated With Infection

Spondyloepimetaphyseal Dysplasia, Strudwick Type

Spondylometaphyseal Dysplasia	Strudwick Syndrome
Dappled Metaphysis Syndrome	Semd, Strudwick Type
Spondylometaepiphyseal Dysplasia Congenita, Strudwick Type	Smed, Strudwick Type
Smd	Smed Strudwick Type
SEMDSTWK	Smed, Type I
Semdc	Smed Type 1
Spondyloepimetaphyseal Dysplasia Strudwick Type	Sed Strudwick
Spondyloepimetaphyseal Dysplasia Congenita, Strudwick Type	Smed Type I
Spondyloepiphyseal Dysplasia Congenita With Dappled Metaphyses	Dysplasia, Spondyloepimetaphyseal, Strudwick Type
Dysplasia, Spondylometaphyseal

Muscular Atrophy

Muscle Wasting	Amyotrophia
Wasting - Muscle	Skeletal Muscle Atrophy

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Avascular Necrosis

Avn

Tooth Disease

Tooth Diseases	Teeth Disease
Tooth Disorders

Spondyloepimetaphyseal Dysplasia

Dysplasia, Spondyloepimetaphyseal

Neuropathy

Peripheral Neuropathy

Peripheral Neuropathies

Pulmonary Edema

Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques

Olmsted Syndrome	Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques
Palmoplantar And Periorificial Keratoderma	Olms

Cystitis

Infective Cystitis	Urocystitis
Pyocystitis

Diabetic Neuropathy

Diabetic Neuropathies

Charcot-Marie-Tooth Disease, Axonal, Type 2e

Charcot-Marie-Tooth Disease Type 2	CMT2E
CMT2S	CMT2Y
Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Disease Type 2y
Charcot-Marie-Tooth Disease Axonal Type 2s	Charcot-Marie-Tooth Disease, Axonal, Type 2s
Charcot-Marie-Tooth Disease, Type 2e	Hereditary Motor And Sensory Neuropathy Type 2
Charcot-Marie-Tooth Neuropathy, Type 2s	Charcot-Marie-Tooth Disease, Axonal, Autosomal Recessive, Type 2s
Charcot-Marie-Tooth Disease, Axonal, Type 2y	Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2y
Charcot-Marie-Tooth Neuropathy, Type 2y	Charcot-Marie-Tooth Disease, Type 2y
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2e	Charcot-Marie-Tooth Neuropathy Type 2e
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2 Due To Vcp Mutation	Cmt2 Due To Vcp Mutation
Charcot-Marie-Tooth Disease Type 2s	Autosomal Dominant Charcot-Marie-Tooth Disease Type 2
Autosomal Dominant Axonal Charcot-Marie-Tooth Disease	Cmt2
Charcot-Marie-Tooth Neuropathy, Type 2e	Hereditary Motor And Sensory Neuropathy Guadalajara Neuronal Type
Hereditary Motor And Sensory Neuropathy Okinawa Type	Autosomal Dominant Axonal Charcot-Marie-Tooth Type 2y
Charcot-Marie-Tooth Neuropathy Type 2y	Autosomal Recessive Axonal Charcot-Marie-Tooth Type 2s
Charcot-Marie-Tooth Neuropathy Type 2s	Charcot-Marie-Tooth Type 2
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2y	Charcot-Marie-Tooth Disease 2e
Charcot-Marie-Tooth Disease Axonal Type 2e	Charcot-Marie-Tooth Disease Neuronal Type 2e
Charcot-Marie-Tooth Disease 2s	Charcot-Marie-Tooth Neuropathy Axonal Type 2s
Charcot-Marie-Tooth Disease 2y	Charcot-Marie-Tooth Disease, Type 2
Hereditary Motor And Sensory-Neuropathy Type Ii

Brain Edema

Cerebral Edema	Intracranial Swelling
Wet Brain

Motor Peripheral Neuropathy

Motor Neuritis	Peripheral Motor Neuropathy
Hereditary Motor And Sensory Neuropathy	Hsmn
Hsmn - Hereditary Sensory And Motor Neuropathy	Neuropathic Muscular Atrophy
Hereditary Sensory And Motor Neuropathy	Hereditary Motor And Sensory Neuropathies

Familial Episodic Pain Syndrome

Feps

Photoparoxysmal Response 1

Photosensitivity Disease	Photodermatitis
Photosensitivity Disorders	PPR1
Ppr	Photosensitivity
Photoconvulsive Reaction	Epilepsy, Photogenic
Photosensitivity Of Skin	Dermatitis, Phototoxic

Brachydactyly

Megalencephalic Leukoencephalopathy With Subcortical Cysts

Vacuolating Megalencephalic Leukoencephalopathy With Subcortical Cysts	Mlc
Van Der Knaap Disease	Lvm
Leukoencephalopathy With Swelling And Cysts	Megalencephaly-Cystic Leukodystrophy
Megalencephalic Leukodystrophy Megalencephaly-Cystic Leukodystorphy Syndrome	Infantile Leukoencephalopathy And Megalencephaly
Leukoencephalopathy With Swelling And A Discrepantly Mild Course	Vacuolating Leukoencephalopathy
Megalencephalic Leukodystrophy	Megalencephaly-Cystic Leukodystrophy Syndrome
Van Der Knaap Syndrome	Leukoencephalopathy, Megalencephalic, With Subcortical Cysts

Neuromyotonia And Axonal Neuropathy, Autosomal Recessive

Gamstorp-Wohlfart Syndrome	Autosomal Recessive Axonal Neuropathy With Neuromyotonia
NMAN	Myokymia, Myotonia, And Muscle Wasting
Aran-Nm	Autosomal Recessive Charcot-Marie-Tooth Disease Type 2 With Neuromyotonia
Autosomal Recessive Neuromyotonia And Axonal Neuropathy	Arcmt2-Nm
Myokymia, Myotonia And Muscle Wasting	Myokymia Myotonia And Muscle Wasting
Isaacs Syndrome

Oculoectodermal Syndrome

Aplasia Cutis Congenita With Epibulbar Dermoids	Toriello-Lacassie-Droste Syndrome
Oculoectodermal Syndrome, Somatic	OES
Aplasia Cutis Congenita-Epibulbar Dermoids Syndrome	Oculo-Ectodermal Syndrome
Toriello Lacassie Droste Syndrome

Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive

Charcot-Marie-Tooth Disease Type 4	Charcot-Marie-Tooth Disease Type 4e
Hereditary Motor And Sensory Neuropathy	Cmt4e
CHN1	Hypomyelinating Neuropathy, Congenital, 1
Charcot-Marie-Tooth Neuropathy Type 4e	Neuropathy, Congenital Hypomyelinating, 1
Ar-Cmt1	Autosomal Recessive Demyelinating Charcot-Marie-Tooth
Cmt4	Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive
Hypomyelination, Severe Congenital	Charcot-Marie-Tooth Disease, Type 4e
Charcot-Marie-Tooth Neuropathy, Type 4e	Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy
Autosomal Recessive Congenital Hypomyelinating Neuropathy	Congenital Amyelinating Neuropathy
Congenital Hypomyelinating Neuropathy Autosomal Recessive	Neuropathy, Congenital Hypomyelinating Or Amyelinating
Severe Congenital Hypomyelination	Hereditary Sensory Motor Neuropathy
Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive	Neuropathy, Hypomyelinating, Congenital, Type 1
Neuropathy, Motor And Sensory, Hereditary	Congenital Hypomyelinating Neuropathy
Hereditary Motor And Sensory Neuropathies	Hereditary Sensorimotor Neuropathy
Hmsn - [Hereditary Motor And Sensory Neuropathy]	Hsmn - [Hereditary Sensory And Motor Neuropathy]
Hereditary Motor And Sensory Neuropathy, Types I-Iv

Charcot-Marie-Tooth Disease And Deafness

Charcot-Marie-Tooth Disease Type 1e	CMT1E
Charcot-Marie-Tooth Disease Type 1	Hereditary Motor And Sensory Neuropathy Type 1
Charcot-Marie-Tooth Disease, Demyelinating, Type 1e	Charcot-Marie-Tooth Disease, Type I
Charcot-Marie-Tooth Neuropathy And Deafness, Autosomal Dominant	Charcot-Marie-Tooth Disease, Type 1e
Charcot-Marie-Tooth Disease Demyelinating Type 1e	Autosomal Dominant Demyelinating Charcot-Marie-Tooth Disease
Cmt1	Charcot-Marie-Tooth Neuropathy Type 1
Autosomal Dominant Charcot-Marie-Tooth Neuropathy And Deafness	Charcot-Marie-Tooth Disease-Deafness
Charcot-Marie-Tooth Type 1	Hmsn1
Hereditary Motor And Sensory Neuropathy 1	Cmt 1e
Charcot Marie Tooth Disease Type 1e	Charcot-Marie-Tooth Disease-Deafness Syndrome
Charcot-Marie-Tooth Disease-Hearing Loss Syndrome	Charcot-Marie-Tooth Disease 1e
Charcot-Marie-Tooth Disease And Deafness Autosomal Dominant	Charcot-Marie-Tooth Neuropathy Type 1e
Charcot-Marie-Tooth Disease, Type Ie	Hereditary Motor And Sensory Neuropathy Type I

Scoliosis

Presbyopia

Subnormal Accommodation

Accommodation Insufficiency Of Old Age

Pseudohypoaldosteronism, Type I, Autosomal Recessive

Autosomal Recessive Pseudohypoaldosteronism Type 1	PHA1B
Pseudohypoaldosteronism Type 1	Pseudohypoaldosteronism, Type I
Generalized Pha1	Generalized Pseudohypoaldosteronism Type 1
Pseudohypoaldosteronism Type 1 Autosomal Recessive	Pha1
Pseudohypoaldosteronism	Pha I, Autosomal Recessive
Autosomal Recessive Pha 1	Pseudohypoaldosteronism Type 1, Recessive
Pseudohypoaldosteronism Type I	Autosomal Recessive Pha1
Pha Type 1	Pseudohypoaldosteronism 1, Autosomal Recessive
Multisystem Pseudohypoaldosteronism	Pha Type I, Autosomal Recessive
Pseudohypoaldosteronism Type I, Autosomal Recessive

Acute Cystitis

Urinary Tract Infection

Recurrent Urinary Tract Infection

Interstitial Cystitis

Bladder Pain Syndrome	Painful Bladder Syndrome
Ulcerative Cystitis	Ic/Bps
Ic/Pbs	Interstitial Cystitis/Bladder Pain Syndrome
Interstitial Cystitis/Painful Bladder Syndrome	Cystitis, Interstitial
Chronic Interstitial Cystitis	Pelvic Congestion Syndrome
Trigonitis

Mucolipidosis Iv

Mucolipidosis Type Iv	ML4
Sialolipidosis	Mucolipidosis Type 4
Ganglioside Sialidase Deficiency	Mliv
Ml Iv	Berman Syndrome
Ganglioside Neuraminidase Deficiency	Ml 4
Mucolipidosis 4	Type Iv Mucolipidosis
Gangliosidoses

Spastic Paraplegia 76, Autosomal Recessive

SPG76	Autosomal Recessive Spastic Paraplegia Type 76
Hereditary Spastic Paraplegia 76	Autosomal Recessive Spastic Paraplegia 76
Paraplegia, Spastic, Autosomal Recessive, Type 76

Somatoform Disorder

Physiological Malfunction Arising From Mental Factor	Psychosomatic Disorder
Psychophysiologic Disorders

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

Bone Development Disease

Cerebral Cavernous Malformations

Cerebral Cavernous Malformation	Cavernous Malformations Of Cns And Retina
Cerebral Cavernous Malformation 1	Cavernous Angiomatous Malformations
Cerebral Capillary Malformations	CCM
Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations	Familial Cavernous Angioma
Cavernous Angioma	Familial Cerebral Cavernous Malformation
Cerebral Cavernous Malformations 1	Cavernous Angioma, Familial
Cam	Cerebral Cavernous Malformations-1
Cavernoma	Central Nervous System Cavernous Hemangioma
Cerebral Cavernous Hemangioma	Familial Cavernous Hemangioma
Familial Cavernous Malformation	Familial Cerebral Cavernous Angioma
Intracerebral Cavernous Hemangioma	CCM1
Cavernous Hemangioma Of The Brain	Cerebral Cavernoma
Cerebral Cavernous Malformations, Type 1	Hemangioma, Cavernous, Central Nervous System
Hemangioma, Cavernous	Angioma, Cavernous

Erythromelalgia

Primary Erythromelalgia	Erythermalgia
Primary Erythermalgia	Mitchell Disease
Familial Erythromelalgia

Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema

Dehydrated Hereditary Stomatocytosis	Hereditary Xerocytosis
Xerocytosis, Hereditary	Pshk1
Pseudohyperkalemia Edinburgh	Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema
DHS1	Dhs
Hereditary Desiccytosis	Dehydrated Hereditary Stomatocytosis 1
Desiccytosis, Hereditary	Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak
Pseudohyperkalemia Familial 1, Due To Red Cell Leak	Desiccytosis Hereditary
Xerocytosis Hereditary	Familial Pseudohyperkalemia 1 Due To Red Cell Leak
Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema	Xerocytosis

Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

Autosomal Recessive Polycystic Kidney Disease	Arpkd
Polycystic Kidney Disease, Autosomal Recessive	Polycystic Kidney And Hepatic Disease 1
Pkhd1	PKD4
Polycystic Kidney Disease 4 With Or Without Hepatic Disease	Polycystic Kidney Disease, Infantile, Type I
Polycystic Kidney Disease, Infantile Type	Polycystic Kidney, Autosomal Recessive
Pkd3, Formerly	Polycystic Kidney Disease 4, With Or Without Hepatic Disease
Arpkd/Chf	Ar-Pkd
Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease	Infantile Polycystic Kidney Disease Type I
Pkd3	Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease
Polycystic Kidney Disease 3, Autosomal Dominant

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Hypertrophic Neuropathy Of Dejerine-Sottas

Dejerine-Sottas Disease	Dejerine-Sottas Syndrome
Charcot-Marie-Tooth Disease Type 3	DSS
Hereditary Motor And Sensory Neuropathy Type Iii	Hmsn3
Dejerine-Sottas Neuropathy	Hmsn Iii
Charcot-Marie-Tooth Disease, Type 3	Cmt3
Dsn	Hmsn 3
Hereditary Motor And Sensory Neuropathy Type 3	Hereditary Motor And Sensory Neuropathy 3
Hypertrophic Neuropathy Of Infancy	Charcot-Marie-Tooth Disease Demyelinating Type 4f
Charcot-Marie-Tooth Disease Type 4f	Charcot-Marie-Tooth Neuropathy Type 4f
Cmt4f	Hereditary Motor And Sensory Neuropathy Iii
Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Distal Arthrogryposis

Arthrogryposis Multiplex Congenita	Arthrogryposis
Congenital Multiple Arthrogryposis	Congenital Arthromyodysplasia
Fibrous Ankylosis Of Multiple Joints	Guerin-Stern Syndrome
Guérin-Stern Syndrome	Myodystrophia Fetalis Deformans
Otto Syndrome	Rocher-Sheldon Syndrome
Rossi Syndrome	Amc
Multiple Congenital Arthrogryposis	Arthrogryposis Syndrome
Arthrogryposis, Distal	Distal Arthrogryposis Syndrome
Freeman-Sheldon Syndrome	Arthrogryposis, Distal, Type 2b
Congenital Multiplex Arthrogryposis	Amyoplasia Congenita
Congenital Amyoplasia	Amc - [Arthrogryposis Multiplex Congenita]

Polycystic Liver Disease

Autosomal Dominant Polycystic Liver Disease	Isolated Polycystic Liver Disease
Pcld	Congenital Cystic Liver Disease
Congenital Hepatic Cyst	Fibrocystic Liver Disease
Isolated Autosomal Dominant Polycystic Liver Disease	Adpcld
Liver Disease, Polycystic	Multiple Cysts Of Liver
Pld - [Polycystic Liver Disease]	Polycystic Liver Disorder
Polycystic Liver	Congenital Polycystic Disease Of Liver
Congenital Polycystic Liver Disease

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Peripheral Nervous System Disease

Peripheral Neuropathy	Peripheral Nerve Disease
Peripheral Nerve Disorders	Neuropathy, Peripheral
Peripheral Neuropathy Due To Vitamin Pyridoxine Hyperalimentation

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19765	GSK2798745	Inhibitor	99.80%	Phase 2

Pre-clinical Phase

Bioactive Molecules (35)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-19608	GSK1016790A		99.93%	Unkown
HY-100208	HC-067047	Antagonist	99.89%	Unkown
HY-100720	GSK2193874	Antagonist	99.91%	Unkown
HY-120691A	GSK205	Antagonist	99.47%	Unkown
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-157131	TRPV2-selective blocker 1	Inhibitor	99.84%	Unkown
HY-19975	RN-1734	Antagonist	99.75%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-19976	RN-1747	Agonist	99.27%	Unkown
HY-114400	TRPV4 agonist-1 free base	Agonist	99.69%	Unkown
HY-120963	N-Oleoyl Taurine		≥99.0%	Unkown
HY-116291	4α-Phorbol 12,13-didecanoate		99.30%	Unkown
HY-160603	PF-05214030	Antagonist	99.19%	Unkown
HY-110270	RN-9893	Antagonist	99.91%	Unkown
HY-120962	N-Arachidonoyl Taurine	Activator	99.0%	Unkown
HY-176464	GSK2220691	Inhibitor	/	Unkown
HY-160900	RN-1665	Antagonist	99.93%	Unkown
HY-124001	N-Docosanoyl taurine	Activator	99.0%	Unkown
HY-120514	JNc-440		98.04%	Unkown
HY-162765	TRPV4-IN-5	Inhibitor	98.77%	Unkown
HY-114400A	TRPV4 agonist-1	Agonist	/	Unkown
HY-112202	GSK3395879	Antagonist	/	Unkown
HY-110270A	RN-9893 hydrochloride	Antagonist	/	Unkown
HY-142620	TRPV4 antagonist 3	Antagonist	/	Unkown
HY-149823	TRPV4 antagonist 4	Antagonist	/	Unkown
HY-157712	08:0 PI(4,5)P2 ammonium		/	Unkown
HY-178236	TRPM5 agonist-1	Inhibitor	/	Unkown
HY-178509	TRPV4-KCa2.3 modulator 1	Activator	/	Unkown
HY-P5315	eNOS pT495 decoy peptide	Activator	/	Unkown
HY-RS15124	TRPV4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W721480	HC-067047 hydrochloride	Antagonist	/	Unkown
HY-N2940	Bisandrographolide A	Activator	/	Unkown
HY-RS16623	Trpv4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23058	Trpv4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	TRPV4	VGNC	VGNC:79112
Mus musculus	TRPV4	MGD	MGI:1926945
Rattus norvegicus	TRPV4	RGD	RGD:69337
Felis catus	TRPV4	VGNC	VGNC:66598
Bos taurus	TRPV4	VGNC	VGNC:36400