2. Gene
  3. Ambra1 - autophagy and beclin 1 regulator 1 Gene

Ambra1 - autophagy and beclin 1 regulator 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Nyw1

Gene ID: 59319 | Gene type: protein coding

About Ambra1

Summary

Predicted to enable GTPase binding activity and ubiquitin protein Ligase binding activity. Involved in cellular response to starvation; negative regulation of cardiac muscle cell apoptotic process; and positive regulation of Autophagy. Predicted to be located in axoneme; cytosol; and phagocytic vesicle. Predicted to be active in intracellular membrane-bounded organelle. Predicted to colocalize with mitochondrion. Orthologous to human AMBRA1 (Autophagy and beclin 1 regulator 1). [provided by Alliance of Genome Resources, Apr 2022]

Ambra1 Products(1)

mRNA Protein Name
NM_001134341.3 NP_001127813.3 activating molecule in BECN1-regulated autophagy protein 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25117440 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to starvation IEP
IEP: Inferred from expression pattern
25117440 RGD
involved in negative regulation of cardiac muscle cell apoptotic process IMP
IMP: Inferred from mutant phenotype
25117440 RGD
involved in positive regulation of autophagy IMP
IMP: Inferred from mutant phenotype
25117440 RGD
involved in response to nutrient levels IEP
IEP: Inferred from expression pattern
23894530 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

activating molecule in BECN1-regulated autophagy protein 1

autophagy/beclin 1 regulator 1

ischemia related factor NYW-1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00643 AMBRA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21820 Ambra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28337 Ambra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ambra1 NCBI NCBI:55626