Nucb2 - nucleobindin 2 Gene

Rattus norvegicus

Also known as p54; Nefa

Gene ID: 59295 | Gene type: protein coding

About Nucb2

Summary

Enables G-protein alpha-subunit binding activity; guanyl-nucleotide exchange factor activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including negative regulation of cell communication; positive regulation of testosterone secretion; and response to melanocyte-stimulating hormone. Located in Golgi medial cisterna and extracellular space. Biomarker of obesity and type 2 diabetes mellitus. Orthologous to human NUCB2 (nucleobindin 2). [provided by Alliance of Genome Resources, Apr 2022]

Nucb2 Products(1)

mRNA	Protein	Name
NM_021663.2	NP_067695.1	nucleobindin-2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	21653697	RGD
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	21653697	RGD
enables tumor necrosis factor receptor binding	IPI IPI: Inferred from physical interaction	20649583	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in insulin metabolic process	IDA IDA: Inferred from direct assay	21828181	RGD
involved in negative regulation of appetite	IMP IMP: Inferred from mutant phenotype	17036007	RGD
involved in negative regulation of cAMP/PKA signal transduction	IDA IDA: Inferred from direct assay	22486620	RGD
involved in negative regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	22486620	RGD
involved in negative regulation of glucagon secretion	IDA IDA: Inferred from direct assay	21828181	RGD
involved in negative regulation of insulin receptor signaling pathway	IDA IDA: Inferred from direct assay	22486620	RGD
involved in positive regulation of fatty acid oxidation	IDA IDA: Inferred from direct assay	21828181	RGD
involved in positive regulation of testosterone secretion	IDA IDA: Inferred from direct assay	22334726	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	20032201	RGD
involved in response to human chorionic gonadotropin	IEP IEP: Inferred from expression pattern	22334726	RGD
involved in response to melanocyte-stimulating hormone	IEP IEP: Inferred from expression pattern	17036007	RGD
involved in response to starvation	IEP IEP: Inferred from expression pattern	22334726	RGD
involved in small GTPase-mediated signal transduction	IDA IDA: Inferred from direct assay	21653697	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi medial cisterna	IDA IDA: Inferred from direct assay	11893086	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	17036007	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

nucleobindin-2

DNA-binding protein NEFA	nesfatin-1
prepronefastin	prepronesfatin

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09655	NUCB2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18672	Nucb2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25158	Nucb2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Nucb2	NCBI	NCBI:4925

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