Kmo - kynurenine 3-monooxygenase Gene

Rattus norvegicus

Gene ID: 59113 | Gene type: protein coding

About Kmo

Summary

Enables kynurenine 3-monooxygenase activity. Involved in several processes, including carboxylic acid metabolic process; cellular response to interleukin-1; and positive regulation of glutamate secretion, neurotransmission. Located in extracellular space and mitochondrial outer membrane. Used to study schizophrenia. Biomarker of mental depression. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Kmo Products(1)

mRNA	Protein	Name
NM_021593.2	NP_067604.1	kynurenine 3-monooxygenase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables kynurenine 3-monooxygenase activity	IDA IDA: Inferred from direct assay	1332540	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-kynurenine metabolic process	IDA IDA: Inferred from direct assay	23690293	RGD
involved in NAD metabolic process	IDA IDA: Inferred from direct assay	1332540	RGD
involved in cellular response to interleukin-1	IEP IEP: Inferred from expression pattern	25675848	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	26524415	RGD
involved in kynurenic acid biosynthetic process	IMP IMP: Inferred from mutant phenotype	15829251	RGD
involved in kynurenine metabolic process	IDA IDA: Inferred from direct assay	26752518	RGD
involved in positive regulation of glutamate secretion	IMP IMP: Inferred from mutant phenotype	15829251	RGD
involved in positive regulation of glutamate secretion, neurotransmission	IMP IMP: Inferred from mutant phenotype	15829251	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	18584961	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	29217494	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	1332540	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

kynurenine 3-monooxygenase

kynurenine 3-hydroxylase

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12347	Ro 61-8048	Inhibitor	99.76%	Unkown
HY-112179	GSK180	Inhibitor	98.34%	Unkown
HY-W748591	Cannflavin A	Inhibitor	99.20%	Unkown
HY-15500	JM6	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Kmo	NCBI	NCBI:8564

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