Med12 - mediator complex subunit 12 Gene

Mus musculus

Also known as Mopa; OPA-1; 230kDa; Tnrc11; Trap230

Gene ID: 59024 | Gene type: protein coding

About Med12

Summary

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; chromatin binding activity; and transcription coactivator activity. Acts upstream of or within several processes, including Wnt signaling pathway; chordate embryonic development; and glial cell development. Part of mediator complex. Is expressed in brain. Human ortholog(s) of this gene implicated in FG syndrome; leiomyosarcoma; major depressive disorder; phobic disorder; and syndromic X-linked intellectual disorder Lujan-Fryns-type. Orthologous to human MED12 (mediator complex subunit 12). [provided by Alliance of Genome Resources, Apr 2022]

Med12 Products(1)

mRNA	Protein	Name
NM_021521.2	NP_067496.2	mediator of RNA polymerase II transcription subunit 12

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	23575864	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	20720539	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	20720539	MGI
enables transcription coactivator activity	IGI IGI: Inferred from genetic interaction	23575864	MGI
enables transcription factor binding	IPI IPI: Inferred from physical interaction	23575864	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within Schwann cell development	IMP IMP: Inferred from mutant phenotype	23575864	MGI
acts upstream of or within Wnt signaling pathway, planar cell polarity pathway	IMP IMP: Inferred from mutant phenotype	20630950	MGI
acts upstream of or within axis elongation involved in somitogenesis	IMP IMP: Inferred from mutant phenotype	20630950	MGI
acts upstream of or within embryonic brain development	IMP IMP: Inferred from mutant phenotype	20589884	MGI
acts upstream of or within embryonic neurocranium morphogenesis	IMP IMP: Inferred from mutant phenotype	20589884	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	20589884	MGI
acts upstream of or within endoderm development	IMP IMP: Inferred from mutant phenotype	20589884	MGI
acts upstream of or within heart development	IMP IMP: Inferred from mutant phenotype	20630950	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	20630950	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	20589884	MGI
acts upstream of or within oligodendrocyte development	IMP IMP: Inferred from mutant phenotype	23575864	MGI
acts upstream of or within post-anal tail morphogenesis	IMP IMP: Inferred from mutant phenotype	20589884	MGI
acts upstream of or within somatic stem cell population maintenance	IMP IMP: Inferred from mutant phenotype	20720539	MGI
acts upstream of or within somitogenesis	IMP IMP: Inferred from mutant phenotype	20589884	MGI
acts upstream of or within spinal cord development	IMP IMP: Inferred from mutant phenotype	20589884	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of mediator complex	IDA IDA: Inferred from direct assay	15340084	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mediator of RNA polymerase II transcription subunit 12

OPA-containing protein 1	mediator of RNA polymerase II transcription, subunit 12 homolog
thyroid hormone receptor-associated protein complex 230 kDa component	trinucleotide repeat containing 11 (THR-associated protein)
trinucleotide repeat containing

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-114965	TP-064	Inhibitor	99.61%	Unkown
HY-100360	MS049	Inhibitor	≥98.0%	Unkown
HY-RS08281	MED12 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-100360A	MS049 dihydrochloride	Inhibitor	/	Unkown
HY-RS08282	MED12L Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18290	Med12 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24768	Med12 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Med12	NCBI	NCBI:9968

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