Gas6 - growth arrest specific 6 Gene

Rattus norvegicus

Gene ID: 58935 | Gene type: protein coding

About Gas6

Summary

Predicted to enable several functions, including cysteine-type endopeptidase inhibitor activity involved in apoptotic process; phosphatidylserine binding activity; and signaling receptor binding activity. Involved in several processes, including activation of protein kinase B activity; positive regulation of intracellular signal transduction; and regulation of renal system process. Located in extracellular space. Used to study glomerulonephritis. Orthologous to human GAS6 (growth arrest specific 6). [provided by Alliance of Genome Resources, Apr 2022]

Gas6 Products(1)

mRNA	Protein	Name
NM_057100.2	NP_476441.2	growth arrest-specific protein 6 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of protein kinase B activity	IDA IDA: Inferred from direct assay	18374201	RGD
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	16285961	RGD
involved in cellular response to glucose stimulus	IDA IDA: Inferred from direct assay	18374201	RGD
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	18374201	RGD
involved in extracellular matrix assembly	IEP IEP: Inferred from expression pattern	18374201	RGD
involved in negative regulation of renal albumin absorption	IEP IEP: Inferred from expression pattern	18374201	RGD
involved in positive regulation of TOR signaling	IDA IDA: Inferred from direct assay	18374201	RGD
involved in positive regulation of glomerular filtration	IDA IDA: Inferred from direct assay	18374201	RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	18374201	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	18374201	RGD
involved in signal transduction	IDA IDA: Inferred from direct assay	18374201	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	18374201	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

growth arrest-specific protein 6

AXL receptor tyrosine kinase ligand	GAS-6
GPF	growth-potentiating factor

Related Agents

Clinical Phase

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P99463	Batiraxcept	Inhibitor	99.91%	Phase 3
HY-P99161	Tilvestamab	Inhibitor	98.08%	Phase 1

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N2995	Poricoic acid A		99.66%	Unkown
HY-119039	RU-301	Inhibitor	99.75%	Unkown
HY-124066	RU-302	Inhibitor	98.72%	Unkown
HY-149092	Anticancer agent 109		/	Unkown
HY-152075	AXL-IN-14	Inhibitor	/	Unkown
HY-RS05285	GAS6 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16715	Gas6 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23150	Gas6 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gas6	NCBI	NCBI:2621
Macaca fascicularis	Gas6	NCBI	NCBI:102133887
Mus musculus	Gas6	NCBI	NCBI:14456

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