GPR158 - G protein-coupled receptor 158 Gene

Homo sapiens

Gene ID: 57512 | Gene type: protein coding

About GPR158

Cytogenetic location: 10p12.1 Genomic coordinates (GRCh38): 10:25,175,001-25,602,229 (from NCBI)

This gene has 4 transcripts (splice variants), 274 orthologues and 1 paralogue. Biased expression in brain (RPKM 11.3), adrenal (RPKM 0.9) and 1 other tissue.

Summary

Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]

GPR158 Products(1)

mRNA	Protein	Name
NM_020752.3	NP_065803.2	probable G-protein coupled receptor 158 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled glycine receptor activity	IDA IDA: Inferred from direct assay	36996198	GOA
enables enzyme activator activity	IDA IDA: Inferred from direct assay	31189666	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	31189666	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	31189666	GOA
involved in regulation of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	36996198	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in plasma membrane	IDA IDA: Inferred from direct assay	31189666	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR158 Protein Structure

7tm_3

0
200
400
600
800
1000
1215 a.a.

Protein Preferred Names

Protein Names

probable G-protein coupled receptor 158

Related Diseases

Diseases

Alias

Smallpox

Variola	Ordinary Smallpox
Alastrim	Amaas

Night Blindness, Congenital Stationary, Type 1b

Congenital Stationary Night Blindness 1b	CSNB1B
Night Blindness, Congenital Stationary, Complete, Autosomal Recessive	Csnb, Complete, Autosomal Recessive
Night Blindness, Congenital Stationary , 1b, Autosomal Recessive	Autosomal Recessive Complete Congenital Stationary Night Blindness
Congenital Stationary Night Blindness 1b Autosomal Recessive	Night Blindness, Congenital Stationary, 1b
Complete Autosomal Recessive Csnb	Complete Congenital Stationary Night Blindness Autosomal Recessive
Blindness, Night, Stationary, Congenital, Type 1b

Cataract 4, Multiple Types

Cataract 4 Multiple Types	CTRCT4
Cca3	Pcc
Aculeiform Cataract	Cataract 4, Multiple Types, With Or Without Microcornea
Cataract, Crystalline Aculeiform	Caca
Cataract, Congenital, Cerulean Type, 3	Congenital Cataract Cerulean Type 3
Cataract Congenital Dominant Non Nuclear	Ccp
Cataract, Nonnuclear Polymorphic Congenital	Cataract, Punctate, Progressive Juvenile-Onset
Cataract 4 Multiple Types With Or Without Microcornea	Autosomal Dominant Nonnuclear Polymorphic Congenital Cataract
Cataract, Polymorphic Congenital	Congenital Cataract Blue Dot Type 3
Congenital Non-Nuclear Polymorphic Cataract	Crystalline Aculeiform Cataract
Punctate, Progressive Juvenile-Onset, Cataract	Cataract, Nonnuclear Polymorphic Congenital, Autosomal Dominant

Congenital Stationary Night Blindness

Night Blindness, Congenital Stationary	Congenital Essential Nyctalopia
Oguchi Disease	Blindness, Night, Stationary, Congenital

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05675	GPR158 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GPR158	VGNC	VGNC:29564
Canis familiaris	GPR158	VGNC	VGNC:41410
Macaca mulatta	GPR158	VGNC	VGNC:103821
Rattus norvegicus	GPR158	RGD	RGD:1305841
Mus musculus	GPR158	MGD	MGI:2441697
Others	GPR158	NCBI

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