PCLO - Pclo piccolo (presynaptic cytomatrix protein) Gene

Rattus norvegicus

Also known as aczonin

Gene ID: 56768 | Gene type: protein coding

About PCLO

Summary

Enables calcium ion binding activity; calcium-dependent phospholipid binding activity; and transcription corepressor binding activity. Involved in several processes, including positive regulation of synaptic vesicle recycling; presynaptic active zone assembly; and regulation of endosome size. Located in several cellular components, including cytoplasmic vesicle; distal axon; and rod spherule. Is active in glutamatergic synapse; parallel fiber to Purkinje cell synapse; and presynaptic active zone cytoplasmic component. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]

PCLO Products(2)

mRNA	Protein	Name
NM_001110797.2	NP_001104267.2	protein piccolo isoform 2
NM_020098.2	NP_064483.2	protein piccolo isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	11285225	RGD
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	11285225	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12473661	RGD
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	25652077	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in modulation of excitatory postsynaptic potential	IMP IMP: Inferred from mutant phenotype	31074746	RGD
involved in positive regulation of synaptic vesicle recycling	IMP IMP: Inferred from mutant phenotype	31074746	RGD
involved in presynaptic active zone assembly	IDA IDA: Inferred from direct assay	22875941	RGD
involved in regulation of endosome size	IMP IMP: Inferred from mutant phenotype	31074746	RGD
involved in regulation of ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	23403927	RGD
involved in synapse organization	IDA IDA: Inferred from direct assay	23403927	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi-associated vesicle	IDA IDA: Inferred from direct assay	22875941	RGD
located in axon	IDA IDA: Inferred from direct assay	11182086	RGD
located in cone cell pedicle	IDA IDA: Inferred from direct assay	11596050	RGD
located in cytoskeleton of presynaptic active zone	IDA IDA: Inferred from direct assay	11596050	RGD
located in dendrite	IDA IDA: Inferred from direct assay	11182086	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	21712437	RGD
located in growth cone	IDA IDA: Inferred from direct assay	11182086	RGD
located in inhibitory synapse	IDA IDA: Inferred from direct assay	11596050	RGD
located in neuromuscular junction	IDA IDA: Inferred from direct assay	17156365	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	11182086	RGD
is active in parallel fiber to Purkinje cell synapse	IDA IDA: Inferred from direct assay	21712437	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17156365	RGD
located in presynaptic active zone	IDA IDA: Inferred from direct assay	11182086	RGD
is active in presynaptic active zone cytoplasmic component	IDA IDA: Inferred from direct assay	21712437	RGD
located in ribbon synapse	IDA IDA: Inferred from direct assay	21712437	RGD
located in rod spherule	IDA IDA: Inferred from direct assay	11596050	RGD
located in synapse	IDA IDA: Inferred from direct assay	10707984	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	11182086	RGD
located in trans-Golgi network	IDA IDA: Inferred from direct assay	16373352	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein piccolo

multidomain presynaptic cytomatrix protein Piccolo	presynaptic cytomatrix protein
protein piccolo-like

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10155	PCLO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22272	Pclo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28795	Pclo Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	PCLO	NCBI	NCBI:27445

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