Gps2 - G protein pathway suppressor 2 Gene

Mus musculus

Also known as GPS-2

Gene ID: 56310 | Gene type: protein coding

About Gps2

Summary

Enables transcription coactivator activity and transcription corepressor activity. Involved in several processes, including negative regulation of protein K63-linked ubiquitination; regulation of signal transduction; and regulation of transcription by RNA polymerase II. Located in mitochondrion and nucleus. Part of transcription repressor complex. Orthologous to human GPS2 (G protein pathway suppressor 2). [provided by Alliance of Genome Resources, Apr 2022]

Gps2 Products(2)

mRNA	Protein	Name
NM_001357906.2	NP_001344835.1	G protein pathway suppressor 2
NM_019726.5	NP_062700.2	G protein pathway suppressor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18218630	MGI
enables transcription coactivator activity	IDA IDA: Inferred from direct assay	24953653	MGI
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	25519902	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in B cell differentiation	IMP IMP: Inferred from mutant phenotype	28039360	MGI
involved in negative regulation of B cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28039360	MGI
involved in negative regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	22424771	MGI
involved in negative regulation of fat cell differentiation	IMP IMP: Inferred from mutant phenotype	22666460	MGI
involved in negative regulation of inflammatory response	IDA IDA: Inferred from direct assay	22424771	MGI
involved in negative regulation of protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	22424771	MGI
involved in negative regulation of protein K63-linked ubiquitination	IMP IMP: Inferred from mutant phenotype	28039360	MGI
involved in negative regulation of toll-like receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	28039360	MGI
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	25519902	MGI
involved in negative regulation of tumor necrosis factor-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	22424771	MGI
involved in positive regulation of peroxisome proliferator activated receptor signaling pathway	IDA IDA: Inferred from direct assay	24953653	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24953653	MGI
involved in regulation of fat cell differentiation	IDA IDA: Inferred from direct assay	24953653	MGI
involved in regulation of lipid metabolic process	IDA IDA: Inferred from direct assay	24953653	MGI
involved in response to mitochondrial depolarisation	IDA IDA: Inferred from direct assay	29499132	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	22424771	MGI
located in mitochondrion	IDA IDA: Inferred from direct assay	29499132	MGI
located in nucleus	IDA IDA: Inferred from direct assay	18218630	MGI
part of transcription repressor complex	IDA IDA: Inferred from direct assay	25519902	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

G protein pathway suppressor 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05758	GPS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20280	Gps2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26788	Gps2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Gps2	NCBI	NCBI:2874

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