Panx1 - pannexin 1 Gene

Mus musculus

Gene ID: 55991 | Gene type: protein coding

About Panx1

Summary

Enables actin filament binding activity and channel activity. Acts upstream of or within several processes, including positive regulation of interleukin-1 production; response to ATP; and response to ischemia. Located in plasma membrane. Is expressed in several structures, including male reproductive gland or organ; metanephros; nervous system; sensory organ; and submandibular gland primordium. Orthologous to human PANX1 (pannexin 1). [provided by Alliance of Genome Resources, Apr 2022]

Panx1 Products(1)

mRNA	Protein	Name
NM_019482.2	NP_062355.2	pannexin-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IPI IPI: Inferred from physical interaction	20086016	MGI
enables actin filament binding	IDA IDA: Inferred from direct assay	20086016	MGI
enables monoatomic anion channel activity	IDA IDA: Inferred from direct assay	22311122	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19780818	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
involved in monoatomic anion transmembrane transport	IDA IDA: Inferred from direct assay	22311122	MGI
acts upstream of or within positive regulation of interleukin-1 alpha production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within positive regulation of macrophage cytokine production	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within response to ATP	IMP IMP: Inferred from mutant phenotype	18490713	MGI
acts upstream of or within response to ischemia	IGI IGI: Inferred from genetic interaction	22147915	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	20086016	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pannexin-1

Panx1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Panx1	Q9JIP4	Kcnab3	Mus musculus	P97382	Anti Tag CoIP	19780818

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103399	Trovafloxacin mesylate	Inhibitor	99.76%	Unkown
HY-A0170	Trovafloxacin	Inhibitor	99.08%	Unkown
HY-B1588	Carbenoxolone	Inhibitor	/	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1137	10Panx	Inhibitor	99.48%	Unkown
HY-B1588S	Carbenoxolone-d4	Inhibitor	/	Unkown
HY-P1138	Scrambled 10Panx	Inhibitor	/	Unkown
HY-RS10021	PANX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16802	Panx1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23243	Panx1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Panx1	NCBI	NCBI:24145

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