WDR11 - WD repeat domain 11 Gene

Homo sapiens

Also known as DR11; HH14; SRI1; BRWD2; WDR15

Gene ID: 55717 | Gene type: protein coding

About WDR11

Cytogenetic location: 10q26.12 Genomic coordinates (GRCh38): 10:120,851,362-120,909,524 (from NCBI)

This gene has 17 transcripts (splice variants), 206 orthologues and is associated with 6 phenotypes. Ubiquitous expression in thyroid (RPKM 17.7), appendix (RPKM 14.7) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of Other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008]

WDR11 Products(1)

mRNA	Protein	Name
NM_018117.12	NP_060587.8	WD repeat-containing protein 11

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20887964	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular protein transport	IDA IDA: Inferred from direct assay	29426865	GOA
involved in vesicle tethering to Golgi	IDA IDA: Inferred from direct assay	29426865	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in ciliary basal body	IDA IDA: Inferred from direct assay	29263200	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	20887964	GOA
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	29426865	GOA
located in nucleus	IDA IDA: Inferred from direct assay	29263200	GOA
located in trans-Golgi network	IDA IDA: Inferred from direct assay	29426865	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR11 Protein Structure

WD40

0
200
400
600
800
1000
1224 a.a.

Protein Preferred Names

Protein Names

WD repeat-containing protein 11

WD repeat domain 15

WDR11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	WDR11	Q9BZH6	EMX1	Homo sapiens	Q04741	Anti Tag CoIP	29263200
Intra	WDR11	Q9BZH6	P10071-PRO_0000406137	Homo sapiens	P10071-PRO_0000406137	Anti Tag CoIP	29263200

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hypogonadotropic Hypogonadism 14 With Or Without Anosmia

HH14	Hypogonadism, Hypogonadotropic, Type 14 With/Without Anosmia

Kallmann Syndrome

Hypogonadism With Anosmia	Kallman'S Syndrome
Anosmic Hypogonadism	Anosmic Idiopathic Hypogonadotropic Hypogonadism
Hypogonadotropic Hypogonadism And Anosmia	Hypogonadotropic Hypogonadism-Anosmia Syndrome
Olfacto-Genital Pathological Sequence	Familial Hypogonadism With Anosmia
Kallman Syndrome	Dysplasia Olfactogenitalis Of De Morsier
Kallmann'S Syndrome	Congenital Hypogonadotropic Hypogonadism With Anosmia

Normosmic Congenital Hypogonadotropic Hypogonadism

Normosmic Idiopathic Hypogonadotropic Hypogonadism

Nihh

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Hypogonadotropic Hypogonadism 7 With Or Without Anosmia

Idiopathic Hypogonadotropic Hypogonadism	HH7
Hypogonadism, Isolated Hypogonadotropic	Ihh
Hypogonadism, Isolated, Hypogonadotropic	Hypogonadotropic Hypogonadism
Isolated Hypogonadotropic Hypogonadism	Hypogonadotropic Hypogonadism 7 Without Anosmia
Congenital Hypogonadotropic Hypogonadism Normosmic	Hh
Klinefelter Syndrome	Isolated Gonadotropin Deficiency

Pituitary Stalk Interruption Syndrome

Ectopic Neurohypophysis

Psis

Hypogonadotropic Hypogonadism

Klinefelter Syndrome	Klinefelter'S Syndrome
Xxy Syndrome	Xxy Trisomy
Hypogonadotropism	47, Xxy
Congenital Idiopathic Hypogonadotropic Hypogonadism	Isolated Congenital Gonadotropin Deficiency
47,Xxy Syndrome	47, Xxy Syndrome
Klinefelters Syndrome	Hypogonadism
Klinefelter Syndrome In Males	Klinefelter Syndrome, Unspecified
Klinefelter Syndrome Karyotype 47, Xxy

Type 1 Diabetes Mellitus 15

Diabetes Mellitus, Insulin-Dependent, 15	Iddm15
Insulin-Dependent Diabetes Mellitus 15	T1D15
Insulin-Dependent Diabetes Mellitus-15

Alopecia Universalis Congenita

Alopecia Universalis	ALUNC
Atrichia, Generalized	Au
Alopecia Areata Universalis	Atrichia Generalized

Submandibular Adenitis

Submandibular Lymphadenitis

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Paraphimosis

Robinow Syndrome, Autosomal Dominant 1

Autosomal Dominant Robinow Syndrome 1	DRS1
Robinow Dwarfism	Fetal Face Syndrome
Acral Dysostosis With Facial And Genital Abnormalities	Robinow, Autosomal Dominant Syndrome, Type 1

Corneal Dystrophy, Band-Shaped

Band Keratopathy

Band-Shaped Keratopathy

Cystic Echinococcosis

Echinococcus Granulosus Infection	Echinococcus Granulosus Infection Of Lung
Echinococcus Granulosus	Echinococcus Granulosus Infection Of Thyroid
Echinococcus Granulosus Infectious Disease	Echinococcus Granulosus Infectious Disease Of Liver
Echinococcus Granulosus Infectious Disease Of Thyroid	Liver Echinococcus Granulosus
Lung Echinococcus Granulosus	Thyroid Echinococcus Granulosus
Unilocular Echinococcosis	Unilocular Hydatid Disease
Hydatid Disease	Hydatidosis
Echinococcosis

Limited Scleroderma

Limited Cutaneous Systemic Sclerosis	Limited Systemic Sclerosis
Systemic Sclerosis Sine Scleroderma	Crest Syndrome
Limited Cutaneous Systemic Scleroderma	Scleroderma, Limited
Systemic Sclerosis, Limited	Progressive Systemic Sclerosis Sine Scleroderma
Scleroderma, Sine	Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome
Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome

Sensorineural Hearing Loss

Sensory Hearing Loss	Sensorineural Deafness
Sensorineural Hearing Loss Disorder	Hearing Loss, Sensorineural
Central Hearing Loss	High Frequency Deafness
High Frequency Hearing Loss	High-Frequency Hearing Loss
Perceptive Deafness	Perceptive Hearing Loss
Perceptive Hearing Loss Or Deafness	Hearing Loss Sensorineural
Deafness Sensorineural	Hearing Loss High-Frequency
Hearing Loss, Central	Hearing Loss, High-Frequency

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10436	PHIP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15761	WDR11 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21408	Phip Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	WDR11	MGD	MGI:1920230
Felis catus	WDR11	VGNC	VGNC:67014
Canis familiaris	WDR11	VGNC	VGNC:48350
Rattus norvegicus	WDR11	RGD	RGD:1587347
Bos taurus	WDR11	VGNC	VGNC:36881
Macaca mulatta	WDR11	VGNC	VGNC:78936

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