DDX43 - DEAD-box helicase 43 Gene

Homo sapiens

Also known as CT13; HAGE

Gene ID: 55510 | Gene type: protein coding

About DDX43

Cytogenetic location: 6q13 Genomic coordinates (GRCh38): 6:73,394,828-73,417,566 (from NCBI)

This gene has 3 transcripts (splice variants), 33 orthologues and 38 paralogues. Biased expression in testis (RPKM 12.4), placenta (RPKM 1.9) and 3 other tissues.

Summary

The protein encoded by this gene is an ATP-dependent RNA helicase in the DEAD-box family and displays tumor-specific expression. [provided by RefSeq, Jul 2008]

DDX43 Products(1)

mRNA	Protein	Name
NM_018665.3	NP_061135.2	probable ATP-dependent RNA helicase DDX43

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DDX43 Protein Structure

KH_1

DEAD

Helicase_C

0
100
200
300
400
500
600
648 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX43

DEAD (Asp-Glu-Ala-Asp) box polypeptide 43

DDX43 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	DDX43	Q9NXZ2	KRTAP10-8	Homo sapiens	P60410	Y2H Array	32296183
Intra	DDX43	Q9NXZ2	KRTAP10-8	Homo sapiens	P60410	Y2H Prey Pooling	32296183
Intra	DDX43	Q9NXZ2	DDX53	Homo sapiens	Q86TM3	Anti Tag CoIP	28514442
Intra	DDX43	Q9NXZ2	DDX53	Homo sapiens	Q86TM3	Anti Tag CoIP	33961781
Intra	DDX43	Q9NXZ2	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	DDX43	Q9NXZ2	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Latent Syphilis

Syphilis, Latent

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03651	DDX43 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	DDX43	VGNC	VGNC:102412
Mus musculus	DDX43	MGD	MGI:3642857
Rattus norvegicus	DDX43	RGD	RGD:1586947
Macaca mulatta	DDX43	VGNC	VGNC:71662

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