AVP - arginine vasopressin Gene

Homo sapiens

Also known as VP; ADH; ARVP; AVRP; AVP-NPII

Gene ID: 551 | Gene type: protein coding

About AVP

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,082,556-3,084,724 (from NCBI)

This gene has 1 transcript (splice variant), 297 orthologues, 1 paralogue and is associated with 2 phenotypes. Low expression observed in reference dataset.

Summary

This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two Other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015]

AVP Products(1)

mRNA	Protein	Name
NM_000490.5	NP_000481.2	vasopressin-neurophysin 2-copeptin preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables V1A vasopressin receptor binding	IPI IPI: Inferred from physical interaction	18402937	GOA
enables cysteine-type endopeptidase inhibitor activity involved in apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
enables neuropeptide hormone activity	IDA IDA: Inferred from direct assay	18402937	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	18402937	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intracellular signal transduction	IDA IDA: Inferred from direct assay	18402937	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	18402937	GOA
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	18538351	GOA
involved in symbiont entry into host cell	IDA IDA: Inferred from direct assay	33713620	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular region	IDA IDA: Inferred from direct assay	33713620	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AVP Protein Structure

Hormone_4

Hormone_5

0
100
164 a.a.

Protein Preferred Names

Protein Names

vasopressin-neurophysin 2-copeptin

antidiuretic hormone

Related Diseases

Diseases

Alias

Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus	Cdi
Pituitary Diabetes Insipidus	Vasopressin Defective Diabetes Insipidus
Vasopressin Deficiency	Central Diabetes Insipidus
Diabetes Insipidus, Neurogenic	Diabetes Insipidus, Primary Central
Diabetes Insipidus, Cranial Type	Diabetes Insipidus Secondary To Vasopressin Deficiency
Diabetes Insipidus, Central	Diabetes Insipidus, Pituitary
NDI	Diabetes Insipidus Cranial Type
Neurogenic Diabetes Insipidus	Primary Central Diabetes Insipidus

Hereditary Central Diabetes Insipidus

Hereditary Cdi

Hereditary Neurogenic Diabetes Insipidus

Diabetes Insipidus

Central Diabetes Insipidus

Neurogenic Diabetes Insipidus	Diabetes Insipidus Cranial Type
Diabetes Insipidus Neurogenic	Diabetes Insipidus Neurohypophyseal
Neurohypophyseal Diabetes Insipidus	Pituitary Diabetes Insipidus
Cdi	Doid:0081055
Diabetes Insipidus	Di - [Diabetes Insipidus]
Adh - [Antidiuretic Hormone Secretion] Deficiency	Diabetes Mellitus Insipidus
Familial Diabetes Insipidus	Antidiuretic Hormone Hyposecretion
Vasopressin Deficiency Syndrome	Primary Central Diabetes Insipidus
Vasopressin Deficiency	Vasopressin Hyposecretion
Diabetes Insipidus Secondary To Vasopressin Deficiency

Inappropriate Adh Syndrome

Syndrome Of Inappropriate Antidiuretic Hormone Secretion	Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone
Siadh	Syndrome Of Inappropriate Vasopressin Secretion
Syndrome Of Inappropriate Secretion Of Adh	Inappropriate Secretion Of Antidiuretic Hormone
Syndrome Of Inappropriate Antidiuresis	Siadh - [Syndrome Of Inappropriate Secretion Of Antidiuretic Hormone]
Antidiuretic Hormone Syndrome	Hormone Secretion
Inadequate Antidiuretic Hormone Secretion Syndrome	Schwartz-Bartter Syndrome
Siad - [Syndrome Of Inappropriate Antidiuresis]	Hypersecretion Of Antidiuretic Hormone

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Pituitary Apoplexy

Pituitary Tumor Apoplexy

Gestational Diabetes Insipidus

Transient Diabetes Insipidus Of Pregnancy	Diabetes Insipidus Gestational
Gestagenic Diabetes Insipidus	Doid:0081057

Dipsogenic Diabetes Insipidus

Primary Polydipsia	Doid:0081058
Psychogenic Polydipsia

Myxedema

Central Pontine Myelinolysis

Myelinolysis, Central Pontine	Osmotic Demyelination Syndrome
Cpm	Myelinolysis Central Pontine
Central Pontine Myelinosis

Lung Oat Cell Carcinoma

Oat Cell Carcinoma	Carcinoma Oat Cell
Carcinoma, Small Cell

Space Motion Sickness

Nephrogenic Syndrome Of Inappropriate Antidiuresis

NSIAD

Tuberculous Encephalopathy

Pituitary Hormone Deficiency, Combined, 2

Panhypopituitarism	Combined Pituitary Hormone Deficiency
CPHD2	Ateliotic Dwarfism With Hypogonadism
Pituitary Dwarfism Iii	Hanhart Dwarfism
Simmond'S Disease	Simmonds' Disease
Cphd	Pituitary Hormone Deficiency, Combined
Hormone Deficiency, Pituitary, Combined, Type 2	Pituitary Dwarfism Type 3
Sheehan Syndrome

Pituitary Infarct

Pituitary Infarction

X-Linked Nephrogenic Diabetes Insipidus

Nephrogenic Diabetes Insipidus Type 1

Doid:0081060

Pneumonia

Acute Pneumonia	Pneumonias
Infectious Pneumonia	Pn - [Pneumonia]
Lobar Pneumonia Nos	Multifocal Pneumonia
Orthostatic Pneumonia	Pneumonia Nos
Chronic Pneumonia Nos	Atypical Pneumonia
Passive Pneumonia	Purulent Pneumonia
Interstitial Lobar Pneumonia	Pneumonia, Unspecified
Pneumonia Due To Chlamydia	Pneumonia Due To Chlamydia Pneumoniae
Pneumonia Due To E. Coli	Escherichia Coli Lobar Pneumonia
Pneumonia Due To H. Influenzae	Pneumonia Due To Hemophilus Influenzae
Bronchopneumonia Due To H. Influenzae	Haemophilus Influenzae Lobar Pneumonia
Bronchopneumonia Due To Hemophilus Influenzae	Pseudomonal Pneumonia
Pseudomonas Pneumonia	Pseudomonas Lobar Pneumonia
Staphylococcal Pneumonia	Staphylococcus Pneumonia
Acute Staphylococcal Pneumonia	Staphylococcal Double Pneumonia
Staphylococcal Lobar Pneumonia	Staphylococcal Purulent Pneumonia
Staphylococcal Bronchopneumonia	Pneumococcal Pneumonia
Pneumococcus Pneumonia	Bronchopneumonia Due To S. Pneumoniae
Pneumococcal Lobar Pneumonia	Streptococcal Pneumoniae Pneumonia
Streptococcus Pneumoniae Lobar Pneumonia	Pyemic Pneumococcal Embolism With Pneumonia
Bronchopneumonia Due To Streptococcus Pneumoniae	Pneumonia Due To Streptococcus, Group B
Group B Streptococcal Pneumonia	Adenovirus Pneumonia
Adenoviral Pneumonia	Adenovirus Viral Pneumonia
Pneumonia Respiratory Syncytial Viral	Parainfluenza Viral Pneumonia
Parainfluenzal Pneumonia	Parainfluenza Virus Pneumonia
Human Metapneumovirus Pneumonia	Human Metapneumovirus Infection Resulting In Pneumonia
Pneumocystis Pneumonia	Plasma Cells Pneumonia

Fanconi Syndrome

Infantile Nephropathic Cystinosis	Adult Fanconi Syndrome
Congenital Fanconi Syndrome	De Toni-Fanconi Syndrome
Fanconi-De Toni Syndrome	Lignac-Fanconi Syndrome
Fanconi Renotubular Syndrome	Primary Fanconi Renotubular Syndrome
De Toni-Debre-Fanconi Syndrome	Adult Fanconi Anemia
Detoni Fanconi Syndrome	Fanconi-De-Toni Syndrome
Primary Fanconi Syndrome	Detoni-Debre-Fanconi Syndrome
Primary Fanconi Renal Syndrome	Fanconi Anemia
Cystinosis, Infantile Nephropathic	Fanconi-Bickel Syndrome
Renal Fanconi Syndrome	Lowe-Bickel Syndrome

Liver Cirrhosis

Cirrhosis	Cirrhosis Of Liver
CIRRH	Cryptogenic Cirrhosis
Cirrhosis, Cryptogenic	Cirrhosis Nos

Suprasellar Meningioma

Developmental And Epileptic Encephalopathy 38

DEE38	Epileptic Encephalopathy, Early Infantile, 38
Eiee38	Developmental And Epileptic Encephalopathy, 38
Glycosylphosphatidylinositol Biosynthesis Defect 23	Gpibd23
Early Infantile Epileptic Encephalopathy 38

Sheehan Syndrome

Postpartum Hypopituitarism	Sheehan'S Syndrome
Postpartum Panhypopituitarism	Postpartum Panhypopituitary Syndrome
Postpartum Pituitary Necrosis	Simmond'S Disease

Pituitary Gland Disease

Pituitary Diseases	Pituitary Dysfunction
Pituitary Disease	Pituitary Deficiency
Pituitary Disorders

Pulmonary Embolism

Pulmonary Artery Embolism	Pulmonary Embolus
Pulmonary Emboli

Coronary Stenosis

Coronary Artery Stenosis

Tuberculous Epididymitis

Tuberculosis Of Epididymis

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

Malignant Olfactory Nerve Neoplasm

Malignant Olfactory Nerve Tumor	Malignant Tumor Of Olfactory Nerve
Primary Malignant Neoplasm Of Olfactory Nerve

Nasal Cavity Benign Neoplasm

Benign Nasal Cavity Neoplasm	Neoplasm Of Nasal Cavity
Tumor Of The Nasal Cavity	Cancer Of Nasal Cavity
Nostril Cancer	Primary Malignant Neoplasm Of Nasal Cavity
Primary Malignant Neoplasm Of Vestibule Of Nose

Hypothalamic Disease

Hypothalamic Diseases	Hypothalamic Dysfunction
Hypothalamic Disorder	Hypothalamic Dysfunction Syndromes

Haemophilus Meningitis

Meningitis, Haemophilus

Alcoholic Cardiomyopathy

Cardiomyopathy, Alcoholic	Alcohol-Induced Heart Muscle Disease
Dilated Cardiomyopathy Secondary To Alcohol

Paralytic Ileus

Adynamic Ileus	Paralytic Ileus Of Bowel
Ileus Nos	Paralysis Of Bowel
Paralysis Of Intestine	Adynamic Intestinal Obstruction
Paralytic Intestinal Ileus

Cranial Nerve Malignant Neoplasm

Cranial Nerve Neoplasms	Malignant Neoplasm Of Cranial Nerve
Malignant Tumor Of Cranial Nerve	Malignant Tumor Of The Cranial Nerve

Porphyria, Acute Intermittent

Acute Intermittent Porphyria	Porphobilinogen Deaminase Deficiency
Pbgd Deficiency	AIP
Porphyria, Swedish Type	Uroporphyrinogen Synthase Deficiency
Ups Deficiency	Porphyria, Acute Intermittent, Nonerythroid Variant
Hydroxymethylbilane Synthase Deficiency	Aip - Acute Intermittent Porphyria
Porphyria Intermittent Acute	Pyrroloporphyria
Hmbs Deficiency	Porphyria Acute Intermittent

Bronchus Cancer

Malignant Neoplasm Of Bronchus And Lung	Bronchus Carcinoma
Bronchogenic Carcinoma	Malignant Neoplasm Of Bronchus Or Lung
Bc - Bronchogenic Carcinoma	Carcinoma, Bronchogenic
Bronchial Neoplasms

Sphenoid Sinusitis

Sphenoidal Sinusitis

Gaba Aminotransferase Deficiency

Gamma-Aminobutyric Acid Transaminase Deficiency	Gamma Aminobutyric Acid Transaminase Deficiency
Gaba Transaminase Deficiency	Gamma-Amino Butyric Acid Transaminase Deficiency
4 Alpha Aminobutyrate Transaminase Deficiency	Abat
Gabat	Gamma Aminobutyrate Transaminase Deficiency

Alcohol-Related Birth Defects

Arbd	Alcohol-Related Birth Defect
Alcohol Related Birth Defect	Fetal Alcohol Syndrome

Fourth Cranial Nerve Palsy

Fourth Nerve Palsy	Fourth Cranial Nerve Paresis
Fourth Or Trochlear Nerve Palsy	4th Nerve Palsy
Fourth Cranial Nerve Paralysis	Superior Oblique Palsy
Trochlear Nerve Palsy	Trochlear Nerve Paralysis
Trochlear Nerve Weakness	Isolated Trochlear Nerve Palsy
Atrophy Of Fourth Cranial Nerve	Atrophy Of Trochlear Nerve

Small Cell Cancer Of The Lung

Small Cell Lung Cancer	Small Cell Lung Carcinoma
Sclc	Small-Cell Cancer Of Lung
Lung Small Cell Carcinoma	Sclc1
Sccl	Cancer, Lung, Small Cell
Small Cell Carcinoma Of Lung	Carcinoma, Small Cell

Hepatorenal Syndrome

Hepato-Renal Syndrome	Hepatorenal Failure
Hrf - [Hepatorenal Failure]	Hepatorenal Degeneration
Hepatic Renal Syndrome	Hepatic Renal Failure
Renal Hepatic Failure	Urohepatic Syndrome

Cranial Nerve Palsy

Cranial Nerve Paralysis	Cranial Nerve Diseases
Cranial Nerve Palsies

Olfactory Neuroblastoma

Esthesioneuroblastoma	Asthesioneuroblastoma
Esthesioneuroepithelioma	Olfactory Esthesioneuroblastoma
Paranasal Sinus Olfactory Neuroblastoma	Esthesioneuroblastoma, Olfactory
Esthesioneuroblastoma Of Nasal Cavity

Hypertensive Encephalopathy

Encephalopathy, Hypertensive

Post-Cardiac Arrest Syndrome

Post Cardiac Syndrome

Bartter Disease

Bartter Syndrome	Bartter'S Syndrome
Aldosteronism With Hyperplasia Of The Adrenal Cortex	Hypokalemic Alkalosis With Hypercalciuria
Potassium Wasting	Juxtaglomerular Hyperplasia With Secondary Aldosteronism
Renal Tubular Normotensive Hypokalemic Alkalosis With Hypercalciuria	Salt-Losing Tubular Disorder, Henle'S Loop Type
Salt-Wasting Tubulopathy, Henle'S Loop Type	Bartters Syndrome

Restless Legs Syndrome

Wed	Willis-Ekbom Disease
Restless Leg Syndrome	Ekbom Syndrome
Wittmaack-Ekbom Syndrome	Willis Ekbom Disease
Ekbom'S Syndrome	Rls
Restless Legs	Restless Legs Syndrome, Susceptibility To

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Fetal Alcohol Spectrum Disorder

Fetal Alcohol Spectrum Disorders

Fetal Alcohol Syndrome

Fetal Alcohol Spectrum Disorders	Arbd
Arnd	Alcohol-Related Birth Defects
Alcohol-Related Neurodevelopmental Disorder	Fas
Fasd	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta Or Breast Milk
Alcohol Related Birth Defect	Alcohol Related Neurodevelopmental Disorder
Alcohol Affecting Fetus Or Newborn Via Placenta Or Breast Milk	Fetus Or Newborn Affected By Alcohol Transmitted Via Placenta And/Or Breast Milk
Dysmorphism Due To Alcohol	Fetal Etoh Syndrome

Substance Dependence

Intracranial Hypertension

Raised Intracranial Pressure

Septooptic Dysplasia

Septo-Optic Dysplasia	De Morsier Syndrome
Growth Hormone Deficiency With Pituitary Anomalies	SOD
Pituitary Hormone Deficiency, Combined, 5	Septo-Optic Dysplasia Spectrum
Septo-Optic Dysplasia With Growth Hormone Deficiency	Pituitary Hormone Deficiency, Combined 5
Hypopituitarism And Septooptic 'Dysplasia'	GHDPA
CPHD5	Dysplasia, Septo-Optic
Kallmann Syndrome

Peripheral Vertigo

Vertigo, Peripheral

Optic Nerve Hypoplasia, Bilateral

Optic Nerve Hypoplasia	Bilateral Optic Nerve Hypoplasia
Optic Nerve Hypoplasia, Familial Bilateral	Familial Bilateral Optic Nerve Hypoplasia
Isolated Optic Nerve Hypoplasia/Aplasia	Optic Nerve Aplasia, Bilateral
Onh	BONH
Bilateral Optic Nerve Aplasia	Hypoplasia, Optic Nerve, Bilateral

Mineral Metabolism Disease

Mineral Metabolism Disorder

Disorder Of Mineral Metabolism

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Alcohol Use Disorder

Alcohol Abuse	Alcoholism
Ethanol Abuse	Alcohol Addiction
Alcohol Dependence	Alcoholic Intoxication, Chronic
Alcohol-Related Disorders

Hypokalemia

Potassium Deficiency	Potassium Deficiency Disorder
Hypopotassemia	Potassium
Potassium [K] Deficiency	Hypokalaemic Syndrome
Hypopotassaemia	Hypopotassaemia Syndrome
Hypokalaemic	Potassium Depletion

Sudden Infant Death Syndrome

SIDS	Sudden Infant Death Syndrome, Susceptibility To
Cot Death	Crib Death
Sudden Death Of Nonspecific Cause In Infancy	Sudden Infant Death
Death, Sudden, Syndrome, Infant

Variegate Porphyria

Porphyria Variegata	Protoporphyrinogen Oxidase Deficiency
VP	Ppox Deficiency
Porphyria, South African Type	Porphyria Variegata, Susceptibility To
Protocoproporphyria	Porphyria Variegate
Porphyria South African Type	Pv
Porphyria, Variegate	Vp - [Variegate Porphyria]

Renal Tubular Transport Disease

Renal Tubular Transport, Inborn Errors

Inborn Renal Tubular Transport Disorder

Autosomal Dominant Polycystic Kidney Disease

Polycystic Kidney Disease, Adult Type	Adpkd
Polycystic Kidney Diseases	Polycystic Kidney, Autosomal Dominant
Congenital Biliary Ectasias	Polycystic Kidney And Hepatic Disease 1
Polycystic Kidney Disease, Autosomal Dominant	Kidney, Polycystic, Disease, Autosomal Dominant
Adult Polycystic Kidney Disease	Polycystic Kidney, Adult Type
Apckd - [Autosomal Polycystic Kidney Disease]

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Analbuminemia

ANALBA	Congenital Analbuminemia
Hypoalbuminemia

Intracranial Berry Aneurysm

Familial Aneurysmal Subarachnoid Hemorrhage	Familial Berry Aneurysm
Familial Intracranial Saccular Aneurysm	Saccular Cerebral Aneurysm
Aneurysm, Intracranial Berry	Aneurysmal Subarachnoid Hemorrhage
Aneurysm, Intracranial Berry, 1

Adrenal Gland Disease

Adrenal Gland Diseases

Adrenal Gland Disorders

Neurogenic Bladder

Neurogenic Dysfunction Of The Urinary Bladder	Neurogenic Urinary Bladder Disorder
Neuropathic Bladder	Bladder Neurogenic
Urinary Bladder, Neurogenic	Neurogenic Urinary Bladder

Substance Abuse

Substance-Related Disorders

Substance Abuse Problem

Hypertension, Essential

Essential Hypertension	Hypertension
High Blood Pressure	Hypertension, Essential, Susceptibility To
Hypertensive Disease	Primary Hypertension
EHT	Hypertension, Salt-Sensitive Essential, Susceptibility To
Hyperpiesia	Idiopathic Hypertension
Hypertensive Disorder	Hypertension, Essential, Susceptibility To, 3
Hypertension, Essential 3	Hypertension, Essential, Salt-Sensitive
Hypertension, Essential, Susceptibility To, 6	Hypertension, Essential 6
Hypertension, Salt-Sensitive Essential	Hypertension, Susceptibility To
Hypertension, Essential, Susceptibility To, 4	Hypertension, Essential 4
Hypertension, Essential, Susceptibility To, 2	Hypertension, Essential 2
Hypertension, Essential, Susceptibility To, 1	Hypertension, Essential 1
Hypertension, Essential, Susceptibility To, 5	Hypertension, Essential 5
Htn	Vascular Hypertensive Disorder
Systemic Primary Arterial Hypertension	Hbp - [High Blood Pressure]
Systemic Arterial Hypertensive Disorder	Elevated Blood Pressure
Arterial Hypertension Nos	Hypertension Nos
Benign Hypertension	Systemic Arterial Hypertension
Systemic Hypertension	Artery Htn
Benign Htn	Vascular Htn
Vascular Hypertension	Cholesterol Hypertension
Cholesterol Htn	Idiopathic Htn
Malignant Hypertension	Malignant Htn
Raised Blood Pressure	Cardiovascular Hypertension
Primary Htn - [Hypertension]	High Arterial Tension
High Blood Pressure Disorder	Ht - [Hypertension]
Htn - [Hypertension]	Hypertensive Vascular Disease
Hypertensive Vascular Degeneration

Cystic Kidney Disease

Renal Cyst	Simple Renal Cyst
Kidney Cysts	Kidney Diseases, Cystic
Renal Cysts	Kidney Cyst
Cystic Kidney	Congenital Cystic Kidney Disease
Cystic Kidney Diseases	Bosniak 1 Cyst

Endometrial Small Cell Carcinoma

Diabetes Mellitus

Diabetes

Deficiency Anemia

Anemia	Deficiency Anemias
Anaemia

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Lipoprotein Quantitative Trait Locus

Coronary Artery Disease	Coronary Artery Anomaly
Coronary Artery Disease, Susceptibility To	Myocardial Ischemia
Congenital Anomaly Of Coronary Artery	Coronary Arteriosclerosis
Coronary Disease	Coronary Heart Disease
Coronary Artery Disorder	LPAQTL
Lpa Deficiency, Congenital	Coronary Artery Abnormality
Coronary Artery Anomaly, Congenital	Chd
Coronary Syndrome	Congenital Malformations Of Coronary Vessels
Malformation Of Coronary Vessels	Congenital Coronary Artery Anomaly
Congenital Coronary Artery Deformity	Congenital Coronary Artery Disorder
Abnormal Coronary Artery	Congenital Coronary Artery Malposition
Congenital Coronary Disease	Congenital Anomaly Of Coronary Arteries

Alcohol Dependence

Alcoholism	Alcohol Dependence, Susceptibility To
Alcohol Dependence, Protection Against	Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against
Alcoholism, Susceptibility To	Alcoholic Intoxication, Chronic
Pharyngeal Neoplasms	Chronic Alcoholism
Dipsomania	Alcohol Addiction
Ethanol Dependence	Chronic Ethanolism
Chronic Alcoholic Disease Nos	Alcoholic Disease Nos
Alcoholic

Supine Hypotensive Syndrome

Maternal Hypotension Syndrome	Antepartum Maternal Hypotension Syndrome
Postpartum Maternal Hypotension Syndrome	Maternal Hypotension Syndrome, Antepartum Condition Or Complication
Maternal Hypotension Syndrome, Postpartum Condition Or Complication	Maternal Hypotension Syndrome, Unspecified Trimester

Polycystic Kidney Disease

Polycystic Kidney Diseases	Pkd
Polycystic Renal Disease	Kidney Disease, Polycystic
Polycystic Kidney, Autosomal Dominant

Autism

Autistic Disorder	Autism Susceptibility 1
Childhood Autism	Autistic Disorder Of Childhood Onset
Infantile Autism	Kanner'S Syndrome
Autistic

Nervous System Disease

Abnormality Of The Nervous System	Nervous System Diseases
Nervous System Disorder

Related Agents

Approval

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P0049	Argipressin	Agonist	98.71%	Unkown
HY-17000	Tolvaptan		99.95%	Yes
HY-18346	Mozavaptan	Antagonist	99.71%	Unkown
HY-123593	Mozavaptan hydrochloride	Antagonist	99.89%	Unkown
HY-P0049A	Argipressin diacetate		/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-W539944	Argipressin acetate		/	Phase 4
HY-10066	Nelivaptan	Antagonist	99.89%	Phase 2

Pre-clinical Phase

Bioactive Molecules (27)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103023	CLP290	Activator	99.87%	Unkown
HY-P1390	d[Cha4]-AVP	Agonist	98.81%	Unkown
HY-RS09357	NLRP3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-P3066	SKF 100398		99.48%	Unkown
HY-157220	Tolvaptan phosphate ester sodium	Antagonist	99.85%	Unkown
HY-P4990A	Pro8-Oxytocin TFA	Activator	99.68%	Unkown
HY-103703	DEAE Cross-linked dextran A 25		/	Unkown
HY-RS06579	IFNAR1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-118768	FMS586 free base		/	Unkown
HY-134454A	Z-Pro-prolinal	Inhibitor	/	Unkown
HY-165484	AVP-13358	Inhibitor	/	Unkown
HY-18346S	Mozavaptan-d6	Antagonist	/	Unkown
HY-P10046	[Deamino-Pen1,Val4,D-Arg8]-vasopressin	Inhibitor	/	Unkown
HY-P1390A	d[Cha4]-AVP TFA	Agonist	/	Unkown
HY-P1747	Pneumadin, rat		/	Unkown
HY-P4010	Desamino(D-3-(3′-pyridyl)-Ala2,Arg8)-Vasopressin	Agonist	/	Unkown
HY-P4990	Pro8-Oxytocin	Activator	/	Unkown
HY-P5007	Copeptin (human)		/	Unkown
HY-RS01280	AVP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W583271	Zn(II) Deuteroporphyrin IX 2,4 bis ethylene glycol	Inhibitor	/	Unkown
HY-111291	ICI 169369 free base	Inhibitor	/	Unkown
HY-118918	YM218 free base	Antagonist	/	Unkown
HY-129333	L-364918	Antagonist	/	Unkown
HY-17000S	Tolvaptan-d7		/	Unkown
HY-P5006	(d(CH2)51,Tyr(Me)2,Dab5,Arg8)-Vasopressin	Antagonist	/	Unkown
HY-RS16746	Avp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23183	Avp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	AVP	VGNC	VGNC:26356
Rattus norvegicus	AVP	RGD	RGD:2184
Felis catus	AVP	VGNC	VGNC:98511
Mus musculus	AVP	MGD	MGI:88121
Macaca mulatta	AVP	VGNC	VGNC:107771
Canis familiaris	AVP	VGNC	VGNC:38317
Macaca fascicularis	AVP	NCBI	NCBI:102121603
Others	AVP	NCBI