RNF186 - ring finger protein 186 Gene

Homo sapiens

Gene ID: 54546 | Gene type: protein coding

About RNF186

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:19,814,029-19,815,283 (from NCBI)

This gene has 1 transcript (splice variant) and 87 orthologues.

Summary

Enables ubiquitin-protein transferase activity. Involved in several processes, including intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein ubiquitination. Located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]

RNF186 Products(1)

mRNA	Protein	Name
NM_019062.2	NP_061935.1	E3 ubiquitin-protein ligase RNF186

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	23896122	GOA
enables ubiquitin protein ligase activity	IDA IDA: Inferred from direct assay	33280498	GOA
enables ubiquitin protein ligase binding	IDA IDA: Inferred from direct assay	23896122	GOA
enables ubiquitin-protein transferase activity	IDA IDA: Inferred from direct assay	23896122	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	23896122	GOA
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23896122	GOA
involved in protein K29-linked ubiquitination	IDA IDA: Inferred from direct assay	23896122	GOA
involved in protein K63-linked ubiquitination	IDA IDA: Inferred from direct assay	23896122	GOA
involved in protein autoubiquitination	IDA IDA: Inferred from direct assay	23896122	GOA
involved in protein localization to mitochondrion	IMP IMP: Inferred from mutant phenotype	23896122	GOA
acts upstream of positive effect regulation of autophagosome assembly	IDA IDA: Inferred from direct assay	33280498	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	23896122	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	23896122	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase RNF186

Related Diseases

Diseases

Alias

Inflammatory Bowel Disease 9

IBD9

Autosomal Dominant Adult-Onset Proximal Spinal Muscular Atrophy

Autosomal Dominant Adult-Onset Proximal Sma	Autosomal Dominant Late-Onset Spinal Muscular Atrophy, Finkel Type
Finkel Disease	Smafk
Adult-Onset Proximal Spinal Muscular Atrophy, Autosomal Dominant	Autosomal Dominant Adult Proximal Spinal Muscular Atrophy
Finkel Late-Adult Type Sma

Immunodeficiency 60

Bach2-Related Immunodeficiency And Autoimmunity	Brida
Imd60

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12070	RNF186 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21922	Rnf186 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	RNF186	MGD	MGI:1914075
Rattus norvegicus	RNF186	RGD	RGD:1596075
Canis familiaris	RNF186	VGNC	VGNC:45649
Bos taurus	RNF186	VGNC	VGNC:34043

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