DDX4 - DEAD-box helicase 4 Gene

Homo sapiens

Also known as VASA

Gene ID: 54514 | Gene type: protein coding

About DDX4

Cytogenetic location: 5q11.2 Genomic coordinates (GRCh38): 5:55,738,061-55,817,157 (from NCBI)

This gene has 14 transcripts (splice variants), 197 orthologues and 38 paralogues. Restricted expression toward testis (RPKM 81.5).

Summary

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which is a homolog of VASA proteins in Drosophila and several Other species. The gene is specifically expressed in the germ cell lineage in both sexes and functions in germ cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]

DDX4 Products(4)

mRNA	Protein	Name
NM_001142549.2	NP_001136021.1	probable ATP-dependent RNA helicase DDX4 isoform 2
NM_001166533.2	NP_001160005.1	probable ATP-dependent RNA helicase DDX4 isoform 3
NM_001166534.2	NP_001160006.1	probable ATP-dependent RNA helicase DDX4 isoform 4
NM_024415.3	NP_077726.1	probable ATP-dependent RNA helicase DDX4 isoform 1

DDX4 Protein Structure

DEAD

Helicase_C

0
200
400
600
724 a.a.

Protein Preferred Names

Protein Names

probable ATP-dependent RNA helicase DDX4

DEAD (Asp-Glu-Ala-Asp) box polypeptide 4

DDX4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81463	DDX4 Antibody (YA1208)	IHC-P	Human

Related Diseases

Diseases

Alias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

Infertility

Spermatogenic Failure, X-Linked, 1

Sertoli Cell-Only Syndrome	Germinal Cell Aplasia
Del Castillo Syndrome	SPGFX1
X-Linked Spermatogenic Failure 1	Congenital Absence Of Germinal Epithelium Of Testes

Testicular Torsion

Spermatic Cord Torsion	Torsion Of Testis
Torsion Of Testicular Cord	Torsion Of Testicle
Torsion Of Spermatic Cord	Torsion Of Spermatic Cord Nos

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Epithelial-Stromal Tgfbi Dystrophy

Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Premature Menopause

Primary Ovarian Insufficiency	Premature Ovarian Failure
Hypergonadotropic Hypogonadism	Premature Ovarian Insufficiency
Menopause - Premature	Menopause Praecox
Menopause Premature	Menopause, Premature
Female Hypergonadotropic Hypogonadism	Hypergonadotrophic Ovarian Failure
Primary Female Hypogonadism	Pof - [Premature Ovarian Failure]
Ovarian Failure	Ovarian Secretion Suppression
Ovary Hyposecretion	Ovary Secretion Deficiency
Premature Menopause Nos

Cryptorchidism, Unilateral Or Bilateral

Cryptorchidism	Undescended Testicle
Undescended Testis	Cryptorchism
Undescended Testicles	CRYPTO
Impaired Testicular Descent	Cryptosporidiosis
Retained Testis	Unilateral Cryptorchidism
Unilateral Undescended Testis	Nondescent Unilateral Testicle
Unilateral Cryptorchism	Ectopic Testis, Unilateral
Bilateral Cryptorchidism	Bilateral Cryptorchism
Bilateral Nondescent Testicle	Bilateral Undescended Testes
Bilateral Ectopic Testes

Congenital Central Hypoventilation Syndrome

Cchs	Haddad Syndrome
Ondine Curse	Ondine Syndrome
Congenital Central Hypoventilation	Congenital Central Alveolar Hypoventilation Syndrome
Congenital Failure Of Autonomic Control	Ondine'S Curse
Primary Alveolar Hypoventilation	Ondine-Hirschsprung Disease
Central Congenital Hypoventilation Syndrome	Congenital Ondine Curse
Idiopathic Congenital Central Alveolar Hypoventilation	Congenital Central Alveolar Hypoventilation-Hirschsprung Disease Syndrome
Ondine-Hirschsprung Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03648	DDX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22135	Ddx4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	DDX4	VGNC	VGNC:71667
Rattus norvegicus	DDX4	RGD	RGD:1308793
Canis familiaris	DDX4	VGNC	VGNC:39856
Mus musculus	DDX4	MGD	MGI:102670
Bos taurus	DDX4	VGNC	VGNC:27966
Felis catus	DDX4	VGNC	VGNC:97397
Others	DDX4	NCBI

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