Ucp2 - uncoupling protein 2 Gene

Rattus norvegicus

Gene ID: 54315 | Gene type: protein coding

About Ucp2

Summary

Predicted to enable Oxidative Phosphorylation uncoupler activity. Involved in several processes, including cellular response to glucose stimulus; liver regeneration; and negative regulation of Insulin secretion involved in cellular response to glucose stimulus. Located in mitochondrion. Used to study hypertension; non-alcoholic fatty liver disease; transient cerebral ischemia; and type 2 diabetes mellitus. Biomarker of congestive heart failure; fatty liver disease (multiple); hypothyroidism; obstructive jaundice; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carotid artery disease; diabetic neuropathy; end stage renal disease; hypertension; and obesity. Orthologous to human UCP2 (uncoupling protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Ucp2 Products(1)

mRNA	Protein	Name
NM_019354.3	NP_062227.2	mitochondrial uncoupling protein 2

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to amino acid starvation	IEP IEP: Inferred from expression pattern	18692019	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	18692019	RGD
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	18079609	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	18079609	RGD
involved in cellular response to lead ion	IEP IEP: Inferred from expression pattern	33576715	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	19104935	RGD
involved in mitochondrial transport	IDA IDA: Inferred from direct assay	12372827	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	18703058	RGD
involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	21172424	RGD
involved in response to dexamethasone	IEP IEP: Inferred from expression pattern	20393169	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	18079609	RGD
involved in response to glucose	IEP IEP: Inferred from expression pattern	18079609	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	17704287	RGD
involved in response to superoxide	IDA IDA: Inferred from direct assay	12372827	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial uncoupling protein 2

UCP 2	Uncoupling protein 2, mitochondrial
solute carrier family 25 member 8	uncoupling protein 2 (mitochondrial, proton carrier)

Related Agents

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-17389	Genipin	Inhibitor	99.55%	Phase 3
HY-138830	TAK-418	Inhibitor	99.81%	Phase 1

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120160	Darglitazone	Agonist	99.19%	Unkown
HY-120160A	Darglitazone Sodium	Agonist	/	Unkown
HY-RS15411	UCP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17900	Ucp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24369	Ucp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ucp2	NCBI	NCBI:7351

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