Apob - apolipoprotein B Gene

Rattus norvegicus

Also known as Aa1064; Ac1-060; ApoB-48; ApoB-100; Apo B-100

Gene ID: 54225 | Gene type: protein coding

About Apob

Summary

This gene product is the main Apolipoprotein of chylomicrons and low density lipoproteins. It occurs in plasma as two main isoforms, apoB-L and apoB-H. Unlike the apoB-48 and apoB-100 structural equivalents in human, which are synthesized exclusively in the gut and liver, respectively, the rat apoBL isoform is also found in rat liver. The intestinal and the hepatic forms of apoB are encoded by a single gene from a single, very long mRNA. The two isoforms share a common N-terminal sequence. The shorter apoB-L protein is produced after RNA editing of the apoB-H transcript at residue 2180 (CAA->UAA), resulting in the creation of a stop codon, and early translation termination. [provided by RefSeq, Jul 2008]

Apob Products(1)

mRNA	Protein	Name
NM_019287.2	NP_062160.2	apolipoprotein B-100 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11830580	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to prostaglandin stimulus	IEP IEP: Inferred from expression pattern	16545597	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	17405916	RGD
involved in response to carbohydrate	IDA IDA: Inferred from direct assay	16672736	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	9402089	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	16719989	RGD
involved in response to selenium ion	IEP IEP: Inferred from expression pattern	16581047	RGD
involved in triglyceride catabolic process	IMP IMP: Inferred from mutant phenotype	9290048	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	16227197	RGD
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	12091487	RGD
part of low-density lipoprotein particle	IDA IDA: Inferred from direct assay	2429674	RGD
part of very-low-density lipoprotein particle	IDA IDA: Inferred from direct assay	12091487	RGD
located in vesicle lumen	IDA IDA: Inferred from direct assay	12091487	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

apolipoprotein B-100

apolipoprotein B (including Ag(x) antigen)	apolipoprotein B PI
apolipoprotein B-48

Apob Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Apob	Q7TMA5	Apoa1	Rattus norvegicus	P04639	Comigration in SDS	18391222
Intra	Apob	Q7TMA5	Apoa1	Rattus norvegicus	P04639	Anti Bait CoIP	18391222

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-148647	Mipomersen	Inhibitor	96.88%	Unkown

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-108764	Mipomersen sodium	Inhibitor	97.50%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Apob	NCBI	NCBI:338

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