2. Gene
  3. Clpp - caseinolytic mitochondrial matrix peptidase proteolytic subunit Gene

Clpp - caseinolytic mitochondrial matrix peptidase proteolytic subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as D17Wsu160e

Gene ID: 53895 | Gene type: protein coding

About Clpp

Summary

Predicted to enable ATP-dependent peptidase activity; ATPase binding activity; and serine-type endopeptidase activity. Predicted to be involved in membrane protein proteolysis and protein quality control for misfolded or incompletely synthesized proteins. Located in mitochondrion. Is expressed in several structures, including extraembryonic component; liver; lung; pancreas; and placenta. Used to study Perrault syndrome. Human ortholog(s) of this gene implicated in Perrault syndrome. Orthologous to human ClpP (caseinolytic mitochondrial matrix peptidase proteolytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Clpp Products(1)

mRNA Protein Name
NM_017393.2 NP_059089.1 ATP-dependent Clp protease proteolytic subunit, mitochondrial precursor
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
10347188 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
10754102 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ATP-dependent Clp protease proteolytic subunit, mitochondrial

ClpP caseinolytic peptidase, ATP-dependent, proteolytic subunit

caseinolytic peptidase, ATP-dependent, proteolytic subunit homolog

caseinolytic protease, ATP-dependent, proteolytic subunit homolog

endopeptidase Clp

putative ATP-dependent Clp protease

Related Agents

Pre-clinical Phase
Bioactive Molecules (20)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N2360 Hinokiflavone Inhibitor 99.81% Unkown
HY-111532 (3R,4R)-A2-32-01 Inhibitor 99.73% Unkown
HY-N1181 Tamarixetin Inhibitor 98.80% Unkown
HY-111532B (3S,4S)-A2-32-01 Inhibitor 98.15% Unkown
HY-164064 Anticancer agent 230 Activator 99.97% Unkown
HY-163319 NCA029 Activator 98.24% Unkown
HY-173048 CLPP-2068 Activator 97.41% Unkown
HY-162650 SL44 Inhibitor / Unkown
HY-152097 (S)-ZG197 Inhibitor / Unkown
HY-152096 (R)-ZG197 Inhibitor / Unkown
HY-P4399 Z-Gly-Gly-Leu-AMC / Unkown
HY-172199 THX6 Activator / Unkown
HY-P4284 Z-GGF-CMK / Unkown
HY-155556 ZG36 Inhibitor / Unkown
HY-168062 ZYZ-17 Activator / Unkown
HY-175082 TBPH Agonist / Unkown
HY-176427 HsClpP activator-1 Activator / Unkown
HY-175596 ACP1-01 Activator / Unkown
HY-175597 ClpP modulator-1 Modulator / Unkown
HY-126046 ACP1b Activator / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Clpp NCBI NCBI:8192