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Results for "

517

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) Acetyl-CoA Carboxylase (1) Adenosine Receptor (1) Amino acid Transporter (1) Biochemical Assay Reagents (1) Cholecystokinin Receptor (2) COX (1) CXCR (1) DNA Methyltransferase (1) Filovirus (1) Fluorescent Dye (3) GnRH Receptor (1) HCV (1) Herbicide (1) LPL Receptor (1) MicroRNA (8) NF-κB (1) NO Synthase (1) PDK-1 (1) Potassium Channel (1) PSMA (1) Ras (2) Reference Standards (1) Topoisomerase (1) TRP Channel (2)
By Research Areas:	Cancer (16) Endocrinology (3) Infection (2) Inflammation/Immunology (4) Metabolic Disease (2) Neurological Disease (3)
Oligonucleotides:	miRNA mimics (2) miRNA agomirs (2) miRNA antagomirs (2) MicroRNAs (8) miRNA inhibitors (2)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-156682

JNT-517	Amino acid Transporter	Metabolic Disease
JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC₅₀ of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU) .

HY-12927

SX-517	CXCR	Inflammation/Immunology
SX-517 is a dual CXCR2/1 antagonist, containing boronic acid. SX-517 inhibits CXCL1-induced Ca ²⁺ flux (IC₅₀=38 nM), and antagonizes CXCL8-induced [(35)S]GTPγS binding (IC₅₀=60 nM) and ERK1/2 phosphorylation. SX-517 has significant ability for inflammation suppression, in both humanized polymorphonuclear (PMN) cells and in murine model .

HY-12747

DC_517 2 Publications Verification	DNA Methyltransferase	Cancer
DC_517 is a DNA methyltransferase 1 (DNMT1) inhibitor, with an IC₅₀ and a K_d of 1.7 μM and 0.91 μM, respectively.

HY-10634

AMG 517 5+ Cited Publications	TRP Channel	Neurological Disease
AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC₅₀ of 0.5 nM.

HY-13842

BX517 2 Publications Verification	PDK-1	Cancer
BX517 is a potent and selective inhibitor of PDK1 with IC₅₀ of 6 nM.

HY-P2360

G12 Ras 5-17	Ras	Others
G12 (Ras 5-17) is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). G12 can be used as a control of mutant Ras peptides studies (such V12) .

HY-P1905

[Gln8]-C517 (LH-RH), chicken	GnRH Receptor	Endocrinology
[Gln8]-C517 (LH-RH), chicken is an avian hypothalamic peptide, which stimulates release of gonadotropins from anterior pituitary, thus regulating reproductive functions.

HY-160005

LMP517 NSC 781517	Topoisomerase	Cancer
LMP517 (NSC 781517) a indenoisoquinoline, is a potent a dual TOP1 and TOP2 inhibitor. LMP517 shows better antitumor activity than its parent compound LMP744 (HY-U00248) against H82 (Small Cell Lung Cancer) xenografts. LMP517 induces TOP1 cleavage complexes (TOP1ccs) and TOP2ccs .

HY-10634R

*AMG 517* (Standard)**	Reference Standards TRP Channel	Neurological Disease
AMG 517 (Standard) is the analytical standard of AMG 517. This product is intended for research and analytical applications. AMG 517 is a potent and selective vanilloid receptor-1 (TRPV1) antagonist with an IC50 of 0.5 nM.

HY-R01558

*hsa-miR-517a-3p mimic*	MicroRNA	Cancer
hsa-miR-517a-3p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-517a-3p mimic hsa-miR-517a-3p mimic

HY-P2360A

G12 TFA Ras 5-17 TFA	Ras	Others
G12 (Ras 5-17) TFA is a wild-type Ras peptide consisted of amino acids 5-17 (KLVVVGAGGVGKS). G12 TFA can be used as a control of mutant Ras peptides studies (such V12) .

HY-114575

Cycloxydim BAS 517-02H	Herbicide Acetyl-CoA Carboxylase	Others
Cycloxydim (BAS 517-02H) is a cyclohexanedione oxime herbicide. Cycloxydim can inhibits the acetyl-CoA carboxylase .

HY-RI01558

*hsa-miR-517a-3p inhibitor*	MicroRNA	Cancer
hsa-miR-517a-3p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-517a-3p inhibitor hsa-miR-517a-3p inhibitor

HY-R01557

*hsa-miR-517-5p mimic*	MicroRNA	Cancer
hsa-miR-517-5p mimics are small, chemically synthesized double-stranded RNAs that mimic endogenous miRNAs and enable miRNA functional analysis by up-regulation of miRNA activity.

hsa-miR-517-5p mimic hsa-miR-517-5p mimic

HY-R01558A

*hsa-miR-517a-3p agomir*	MicroRNA	Cancer
hsa-miR-517a-3p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-517a-3p agomir hsa-miR-517a-3p agomir

HY-P991204

Anti-PSMA Antibody ARX517 antibody	PSMA	Cancer
Anti-PSMA Antibody is a humanized IgG1 monoclonal antibody that targets PSMA. Anti-PSMA Antibody is the antibody part of the ADC molecule ARX517. Recommend Isotype Controls: Human IgG1 kappa, Isotype Control (HY-P99001) .

HY-RI01558A

*hsa-miR-517a-3p antagomir*	MicroRNA	Cancer
hsa-miR-517a-3p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-517a-3p antagomir hsa-miR-517a-3p antagomir

HY-RI01557

*hsa-miR-517-5p inhibitor*	MicroRNA	Cancer
hsa-miR-517-5p inhibitors are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA inhibitors have full-length nucleotide 2'-methoxy modification. The miRNA inhibitors strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning.

hsa-miR-517-5p inhibitor hsa-miR-517-5p inhibitor

HY-R01557A

*hsa-miR-517-5p agomir*	MicroRNA	Cancer
hsa-miR-517-5p agomirs are chemically-modified double-strand miRNA mimics with modified mature miRNA strand: 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 3' end cholesterol group, and full-length nucleotide 2'-methoxy modification. They are designed to mimic endogenous miRNAs and recommended for miRNA functional studies. Compared with miRNA mimics, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-517-5p agomir hsa-miR-517-5p agomir

HY-RI01557A

*hsa-miR-517-5p antagomir*	MicroRNA	Cancer
hsa-miR-517-5p antagomirs are chemically-modified oligonucleotides that hybridize with mature miRNAs. The miRNA antagomirs have 2 phosphorothioates at the 5' end, 4 phosphorothioates at the 3' end, 1 cholesterol group at the 3' end, and full-length nucleotide 2'-methoxy modification. The miRNA antagomirs strongly compete with mature miRNAs to prevent the complementary pairing of miRNAs and their target genes, thereby inhibiting miRNAs from functioning. Stability of miRNA antagomirs appears to be significantly higher than miRNA inhibitors, they exhibits enhanced cellular uptake, stability and regulatory activity in vivo.

hsa-miR-517-5p antagomir hsa-miR-517-5p antagomir

HY-D0056

5-Carboxyfluorescein diacetate N-succinimidyl ester Maximum Cited Publications 7 Publications Verification	Fluorescent Dye	Others
5-Carboxyfluorescein diacetate N-succinimidyl ester is a cell permeable dye (Ex=492 nm, Em=517 nm). 5-Carboxyfluorescein diacetate N-succinimidyl ester can label cells by covalently binding to intracellular molecules. 5-Carboxyfluorescein diacetate N-succinimidyl ester is used to track lymphocyte migration and proliferation .

HY-D1688

Flubida-2	Fluorescent Dye	Others
Flubida-2 is a cell permeable dye which can be hydrolyzed to Fubi-2 by endoesterases in cells (after hydrolysis, Ex=492 nm, Em=517 nm). Flubida-2 can be used to detect pH at a specific site in a cell organelle by directing the probe to where avidin fusion proteins are located .

HY-P1593

Mini Gastrin I, human	Cholecystokinin Receptor	Endocrinology Cancer
Mini Gastrin I, human is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.

HY-P1593A

Mini Gastrin I, human TFA	Cholecystokinin Receptor	Endocrinology Cancer
Mini Gastrin I, human (TFA) is a shorter version of human gastrin, consists of amino acids 5-17 of the parent peptide.

HY-W009384

1,4-Dioxacycloheptadecane-5,17-dione Ethylene brassylate	Biochemical Assay Reagents	Others
1,4-Dioxacycloheptadecane-5,17-dione is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-173269

5-HT2A receptor agonist-7	5-HT Receptor	Others
5-HT2A receptor agonist-7 (517) is a 5-HT2A modulator, with an EC₅₀ of <100 nM .

HY-129558

UK-1	HCV	Infection Cancer
UK-1 is a cytotoxic metabolite from Streptomyces sp. 517-02 and exerts a wide spectrum of potent anticancer activities . UK-1 also inhibits HCV replication .

HY-131008

Fluorescein tyramide 1 Publications Verification	Fluorescent Dye	Others
Fluorescein tyramide is a green fluorescent reagent (λ_abs: 494 nm; λ_em: 517 nm). Fluorescein tyramide is widely used for tyramide signal amplification (TSA) with a low-abundance in IHC, ICC, in situ hybridization (FISH) and flow cytometry (FCM) applications .

HY-146814

EBOV/MARV-IN-3	Filovirus	Infection
EBOV/MARV-IN-3 (compound 32) is a potent EBOV and MARV inhibitor with IC₅₀ values of 0.5, 1.2 µM, respectively. EBOV/MARV-IN-3 binds to the hydrophobic pocket close to EBOV Y517. EBOV/MARV-IN-3 shows antiviral activity .

HY-155183

A3AR agonist 1	Adenosine Receptor	Inflammation/Immunology Cancer
A3AR agonist 1 (Compound 12) is an A3AR agonist (K_i: 25.8 nM). A3AR agonist 1 stimulates β-arrestin2 recruitment, with an EC₅₀ value of 5.17 nM. A3AR agonist 1 can be used for research of inflammatory diseases, ischemia, cancer, neuropathic pain, liver diseases, etc .

HY-164417

Kv7.2/Kv7.3 activator-1	Potassium Channel	Neurological Disease
Kv7.2/Kv7.3 activator-1 (compound 517) is a potent Kv7.2/Kv7.3 channel activator with an EC₅₀ value of ＜1 µM. Kv7.2/Kv7.3 activator-1 has the potential for the research of neurological diseases .

HY-168070

COX-2-IN-48	COX NF-κB NO Synthase	Inflammation/Immunology
COX-2-IN-48 (5-25), a COX-2 inhibitor with an IC₅₀ of 51.7 nM for human COX-2, exerts anti-inflammatory and analgesic effects in various rodent models by inhibiting NF-κB pathway. COX-2-IN-48 (5-25) inhibits the degradation of IκB, the phosphorylation and nuclear translocation of NF-κB p65, and the expression of COX-2 and iNOS .

HY-125778

Cochlioquinone B	Others	Metabolic Disease
Cochlioquinone is a sesquiterpene metabolite originally isolated from C. miyabeanus. It is a phytotoxin that inhibits root growth of finger millet (E. coracana) and rice plants (O. sativa) by 59.9 and 51.7%, respectively, when used at a concentration of 100 ppm.2 Cochlioquinone B inhibits NADH oxidase and NADH-2,3-dimethoxy-5-pentyl-1,4-benzoquinone reductase from bovine heart mitochondria.

HY-125881

ASP1126	LPL Receptor	Inflammation/Immunology
ASP1126 is a selective and orally active sphingosine-1-phosphate (S1P) agonist, with EC₅₀ values of 7.12 nM, 517 nM for hS1P₁ and hS1P₃, respectively. ASP1126 decreases the number of peripheral lymphocytes, naive T cells, central memory T cells and effector memory T cells in the peripheral blood. ASP1126 has the potential to be applied in clinical transplantation with improved safety profile .

Cat. No.	Product Name	Type