2. Gene
  3. Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

Gne - glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as NM; DMRV; IBM2; Uae1; GLCNE; 2310066H07Rik

Gene ID: 50798 | Gene type: protein coding

About Gne

Summary

Predicted to enable N-acylmannosamine kinase activity and UDP-N-acetylglucosamine 2-epimerase activity. Predicted to be involved in UDP-N-acetylglucosamine metabolic process. Predicted to act upstream of or within N-acetylneuraminate metabolic process. Predicted to be located in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and respiratory system. Human ortholog(s) of this gene implicated in GNE myopathy and sialuria. Orthologous to human GNE (glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Gne Products(3)

mRNA Protein Name
NM_001190414.2 NP_001177343.1 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 1
NM_001357539.1 NP_001344468.1 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 3
NM_015828.3 NP_056643.3 bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase isoform 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables N-acylmannosamine kinase activity IMP
IMP: Inferred from mutant phenotype
38237079 MGI
enables UDP-N-acetylglucosamine 2-epimerase activity IDA
IDA: Inferred from direct assay
10745088 MGI
enables UDP-N-acetylglucosamine 2-epimerase activity IMP
IMP: Inferred from mutant phenotype
11929971 MGI
Biological Process GO Annotation Evidence Reference Source
involved in N-acetylneuraminate biosynthetic process IMP
IMP: Inferred from mutant phenotype
11929971 MGI
Cellular Component GO Annotation Evidence Reference Source
is active in cytosol IDA
IDA: Inferred from direct assay
10745088 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

bifunctional UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

UDP-GlcNAc-2-epimerase/ManAc kinase

UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase

Related Agents

Clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-13246 Apitolisib 99.29% Phase 2
HY-128850 N-Acetyl-D-mannosamine 99.58% Phase 2
Pre-clinical Phase
Bioactive Molecules (76)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-100742A (R)-GNE-140 Inhibitor 99.73% Unkown
HY-147214 GNE-7883 Inhibitor 99.54% Unkown
HY-108696 GNE-781 Inhibitor 98.16% Unkown
HY-100343 GNE-495 Inhibitor 99.49% Unkown
HY-12947 GNE-3511 Inhibitor 99.54% Unkown
HY-108435 GNE-049 Inhibitor 98.01% Unkown
HY-107986 GNE-6776 Inhibitor 98.03% Unkown
HY-15796 GNE0877 Inhibitor 99.81% Unkown
HY-129937A GNE-987 Inhibitor 99.73% Unkown
HY-15766 GNE-617 Inhibitor 99.58% Unkown
HY-12632 GNE 2861 Inhibitor 99.16% Unkown
HY-18163 GNE-7915 Inhibitor 99.82% Unkown
HY-100726 GNE-272 Inhibitor 99.60% Unkown
HY-100742 GNE-140 racemate Inhibitor 99.38% Unkown
HY-120028 GNE-207 Inhibitor 99.94% Unkown
HY-149026 GNE-064 Inhibitor 99.65% Unkown
HY-154984 JET-209 Degrader 98.07% Unkown
HY-112937 GNE-6640 Inhibitor 99.91% Unkown
HY-107409 GNE 5729 Agonist 99.50% Unkown
HY-158113 CBPD-409 Degrader 98.97% Unkown
HY-12763 GNE-317 Inhibitor 98.76% Unkown
HY-129939 PROTAC BRD4 ligand-1 Inhibitor 99.85% Unkown
HY-145341 GNE-149 Antagonist 99.18% Unkown
HY-112803 GNE-371 98.21% Unkown
HY-114332 GNE-8505 Inhibitor 99.86% Unkown
HY-10811 GNE-493 Inhibitor 99.81% Unkown
HY-133736 PROTAC BRD4 Degrader-5-CO-PEG3-N3 99.73% Unkown
HY-19775 GNE-6468 Antagonist 98.02% Unkown
HY-135892 GNE-1858 Inhibitor 99.23% Unkown
HY-12628 GNE-618 Inhibitor 99.89% Unkown
HY-123621 GNE-375 Inhibitor 99.93% Unkown
HY-100742B (S)-GNE-140 Inhibitor 99.07% Unkown
HY-15883 GNE-900 99.21% Unkown
HY-11042 GNE-477 Inhibitor 98.75% Unkown
HY-129938 PROTAC BRD4 Degrader-24 99.61% Unkown
HY-12282 GNE-9605 Inhibitor 99.51% Unkown
HY-12410 GNE-9822 Inhibitor ≥95.0% Unkown
HY-129527 GNE-9278 Modulator 99.91% Unkown
HY-142160 GNE-9815 Inhibitor 98.94% Unkown
HY-U00428A GNE 220 hydrochloride Inhibitor 98.22% Unkown
HY-141551 GNE-274 Degrader 98.00% Unkown
HY-150289 GNE-235 98.45% Unkown
HY-112279 GNE-131 Inhibitor 98.15% Unkown
HY-149056 GNE-6893 Inhibitor 99.94% Unkown
HY-117865 GNE-886 Inhibitor 99.81% Unkown
HY-18163A GNE-7915 tosylate Inhibitor 99.06% Unkown
HY-10812 GNE-490 Inhibitor 96.29% Unkown
HY-108337 GNE-0723 Agonist 98.74% Unkown
HY-123824 GNE-0439 Inhibitor 99.80% Unkown
HY-15766A GNE-617 hydrochloride Inhibitor 99.16% Unkown
HY-162553 GNE7599 / Unkown
HY-19774 GNE-0946 Inhibitor 98.09% Unkown
HY-134592 Piperidine-GNE-049-N-Boc 98.48% Unkown
HY-107498 GNE-8324 Modulator 98.88% Unkown
HY-149056A (3S,4R)-GNE-6893 Inhibitor 99.49% Unkown
HY-16983 GNE-3500 Antagonist 98.90% Unkown
HY-RS05551 GNE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-U00428 GNE 220 Inhibitor / Unkown
HY-126291 GNE-616 Inhibitor / Unkown
HY-132294 GNE-502 Inhibitor 99.73% Unkown
HY-101783 GNE-955 Inhibitor / Unkown
HY-128585 GNE684 Inhibitor / Unkown
HY-107409B (S,S)-GNE 5729 99.65% Unkown
HY-107423 GNE 6901 Agonist 99.31% Unkown
HY-124153 GNE-431 Inhibitor / Unkown
HY-129937 (S)-GNE-987 Inhibitor / Unkown
HY-132294A (1S,3R)-GNE-502 Inhibitor / Unkown
HY-13847 GNE-555 Inhibitor / Unkown
HY-141551B (R)-GNE-274 / Unkown
HY-148238 GNE-2256 Inhibitor / Unkown
HY-15882 GNE-783 / Unkown
HY-16984 GNE-4997 Inhibitor / Unkown
HY-174261 KRAS-IN-5 Inhibitor / Unkown
HY-12517 GNE-293 Inhibitor / Unkown
HY-RS16774 Gne Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23214 Gne Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gne NCBI NCBI:10020