Polg2 - polymerase (DNA directed), gamma 2, accessory subunit Gene

Mus musculus

Also known as p55; mtPolB; polG-beta

Gene ID: 50776 | Gene type: protein coding

About Polg2

Summary

Enables DNA-directed DNA Polymerase activity and identical protein binding activity. Acts upstream of or within in utero embryonic development; mitochondrion organization; and respiratory electron transport chain. Located in mitochondrion. Is expressed in early conceptus and secondary oocyte. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 4 and mitochondrial DNA depletion syndrome. Orthologous to human POLG2 (DNA Polymerase gamma 2, accessory subunit). [provided by Alliance of Genome Resources, Apr 2022]

Polg2 Products(2)

mRNA	Protein	Name
NM_001353435.1	NP_001340364.1	DNA polymerase subunit gamma-2, mitochondrial isoform 1b
NM_015810.2	NP_056625.2	DNA polymerase subunit gamma-2, mitochondrial isoform 1a

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-directed DNA polymerase activity	IDA IDA: Inferred from direct assay	10666468	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	11172710	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	23197651	MGI
acts upstream of or within mitochondrial DNA metabolic process	IMP IMP: Inferred from mutant phenotype	23197651	MGI
acts upstream of or within mitochondrial DNA replication	IMP IMP: Inferred from mutant phenotype	23197651	MGI
acts upstream of or within mitochondrion organization	IMP IMP: Inferred from mutant phenotype	23197651	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

DNA polymerase subunit gamma-2, mitochondrial

DNA polymerase gamma accessory 55 kDa subunit	mitochondrial DNA polymerase accessory subunit
mitochondrial polymerase gamma 2

Polg2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Polg2	Q9QZM2	Polg2	Mus musculus	Q9QZM2	Density Sedimentation	11172710
Intra	Polg2	Q9QZM2	Polg2	Mus musculus	Q9QZM2	X-Ray Diffraction	11172710

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10830	POLG2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22735	Polg2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Polg2	NCBI	NCBI:11232

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