NPTX2 - neuronal pentraxin 2 Gene

Homo sapiens

Also known as NP2; NARP; NP-II

Gene ID: 4885 | Gene type: protein coding

About NPTX2

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:98,617,285-98,629,869 (from NCBI)

This gene has 2 transcripts (splice variants), 274 orthologues and 5 paralogues. Biased expression in brain (RPKM 31.6), testis (RPKM 20.6) and 4 other tissues.

Summary

This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]

NPTX2 Products(1)

mRNA	Protein	Name
NM_002523.3	NP_002514.1	neuronal pentraxin-2 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	30833544	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27986928	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27986928	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NPTX2 Protein Structure

Pentaxin

0
100
200
300
400
431 a.a.

Protein Preferred Names

Protein Names

neuronal pentraxin-2

apexin

NPTX2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NPTX2	P47972	FZD6	Homo sapiens	O60353	Anti Bait CoIP	30833544
Intra	NPTX2	P47972	FZD6	Homo sapiens	O60353	Anti Tag CoIP	30833544
Intra	NPTX2	P47972	FZD6	Homo sapiens	O60353	IF	30833544

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Narcolepsy

Paroxysmal Sleep	Gelineau Syndrome
Narcoleptic Syndrome	Narcolepsy-Cataplexy Syndrome
Cataplexy And Narcolepsy	Narcolepsy, Without Cataplexy
Gelineau'S Syndrome	Narcolepsy With Or Without Cataplexy
Narcolepsy Nos

Diabetes Insipidus, Neurohypophyseal

Neurohypophyseal Diabetes Insipidus	Cdi
Pituitary Diabetes Insipidus	Vasopressin Defective Diabetes Insipidus
Vasopressin Deficiency	Central Diabetes Insipidus
Diabetes Insipidus, Neurogenic	Diabetes Insipidus, Primary Central
Diabetes Insipidus, Cranial Type	Diabetes Insipidus Secondary To Vasopressin Deficiency
Diabetes Insipidus, Central	Diabetes Insipidus, Pituitary
NDI	Diabetes Insipidus Cranial Type
Neurogenic Diabetes Insipidus	Primary Central Diabetes Insipidus

Diabetes Insipidus

Dipsogenic Diabetes Insipidus

Primary Polydipsia	Doid:0081058
Psychogenic Polydipsia

Central Diabetes Insipidus

Neurogenic Diabetes Insipidus	Diabetes Insipidus Cranial Type
Diabetes Insipidus Neurogenic	Diabetes Insipidus Neurohypophyseal
Neurohypophyseal Diabetes Insipidus	Pituitary Diabetes Insipidus
Cdi	Doid:0081055
Diabetes Insipidus	Di - [Diabetes Insipidus]
Adh - [Antidiuretic Hormone Secretion] Deficiency	Diabetes Mellitus Insipidus
Familial Diabetes Insipidus	Antidiuretic Hormone Hyposecretion
Vasopressin Deficiency Syndrome	Primary Central Diabetes Insipidus
Vasopressin Deficiency	Vasopressin Hyposecretion
Diabetes Insipidus Secondary To Vasopressin Deficiency

Gestational Diabetes Insipidus

Transient Diabetes Insipidus Of Pregnancy	Diabetes Insipidus Gestational
Gestagenic Diabetes Insipidus	Doid:0081057

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09506	NPTX2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20456	Nptx2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26965	Nptx2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NPTX2	VGNC	VGNC:43934
Bos taurus	NPTX2	VGNC	VGNC:32219
Macaca mulatta	NPTX2	VGNC	VGNC:75392
Rattus norvegicus	NPTX2	RGD	RGD:1309447
Mus musculus	NPTX2	MGD	MGI:1858209
Felis catus	NPTX2	VGNC	VGNC:68537
Others	NPTX2	NCBI

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