Aim2 - absent in melanoma 2 Gene

Mus musculus

Also known as Gm1313; Ifi210

Gene ID: 383619 | Gene type: protein coding

About Aim2

Summary

Enables double-stranded DNA binding activity and identical protein binding activity. Involved in positive regulation of macromolecule metabolic process; pyroptosis; and regulation of defense response. Acts upstream of or within cellular response to interferon-beta. Located in cytoplasm. Part of AIM2 inflammasome complex. Orthologous to human AIM2 (absent in melanoma 2). [provided by Alliance of Genome Resources, Apr 2022]

Aim2 Products(1)

mRNA	Protein	Name
NM_001013779.2	NP_001013801.2	interferon-inducible protein AIM2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	19158679	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	19158676	MGI
enables pattern recognition receptor activity	IDA IDA: Inferred from direct assay	23567559	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	19158679	MGI
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	26197926	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in AIM2 inflammasome complex assembly	IDA IDA: Inferred from direct assay	23567559	MGI
involved in DNA damage response	IDA IDA: Inferred from direct assay	27846608	MGI
involved in T cell homeostasis	IDA IDA: Inferred from direct assay	33505023	MGI
involved in activation of innate immune response	IDA IDA: Inferred from direct assay	19158676	MGI
involved in brain development	IDA IDA: Inferred from direct assay	32350463	MGI
acts upstream of or within cellular response to interferon-beta	IDA IDA: Inferred from direct assay	19158679	MGI
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA IDA: Inferred from direct assay	26095253	MGI
involved in neuron cellular homeostasis	IDA IDA: Inferred from direct assay	32350463	MGI
involved in positive regulation of cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	19158676	MGI
involved in positive regulation of cysteine-type endopeptidase activity	IMP IMP: Inferred from mutant phenotype	19131592	MGI
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	19158675	MGI
involved in positive regulation of interleukin-1 beta production	IDA IDA: Inferred from direct assay	19158676	MGI
acts upstream of or within positive regulation of interleukin-1 beta production	IGI IGI: Inferred from genetic interaction	23997220	MGI
involved in positive regulation of interleukin-1 beta production	IMP IMP: Inferred from mutant phenotype	19158675	MGI
involved in pyroptotic inflammatory response	IDA IDA: Inferred from direct assay	19158676	MGI
involved in regulation of behavior	IDA IDA: Inferred from direct assay	32350463	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of AIM2 inflammasome complex	IDA IDA: Inferred from direct assay	19158679	MGI
is active in cytoplasm	IDA IDA: Inferred from direct assay	19158679	MGI
located in cytoplasm	IDA IDA: Inferred from direct assay	19158679	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	27846608	MGI
is active in site of double-strand break	IDA IDA: Inferred from direct assay	27846608	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

interferon-inducible protein AIM2

ifi-210	interferon-inducible protein 210
interferon-inducible protein p210

Aim2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Aim2	Q91VJ1	Aim2	Mus musculus	Q91VJ1	Crosslink	19158676
Intra	Aim2	Q91VJ1	Ralb	Mus musculus	Q9JIW9	Confocal	22286270
Intra	Aim2	Q91VJ1	Exoc8	Mus musculus	Q6PGF7	Confocal	22286270

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0822	Shikonin	Inhibitor	99.80%	Unkown
HY-144226	NLRP3/AIM2-IN-3	Inhibitor	98.23%	Unkown
HY-150751	ODN TTAGGG	Antagonist	99.87%	Unkown
HY-150751C	ODN TTAGGG sodium	Antagonist	93.80%	Unkown
HY-152670	JC2-11	Inhibitor	98.03%	Unkown
HY-144223	NLRP3/AIM2-IN-2	Inhibitor	99.93%	Unkown
HY-138646	Poly(deoxyadenylic-thymidylic) acid sodium	Activator	/	Unkown
HY-130480	Fructose-arginine	Inhibitor	98.32%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Aim2	NCBI	NCBI:9447

Name
Email *

	Sorry, but the email address you supplied was invalid.