Unc13a - unc-13 homolog A Gene

Mus musculus

Also known as Munc13-1; 2410078G03Rik

Gene ID: 382018 | Gene type: protein coding

About Unc13a

Summary

Enables diacylglycerol binding activity. Involved in several processes, including positive regulation of glutamate receptor signaling pathway; positive regulation of synaptic plasticity; and synaptic vesicle exocytosis. Acts upstream of or within several processes, including amyloid-beta metabolic process; chemical synaptic transmission; and modulation of chemical synaptic transmission. Located in calyx of Held and neuromuscular junction. Is active in glutamatergic synapse and presynaptic active zone. Is expressed in nervous system and neural retina. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human UNC13A (unc-13 homolog A). [provided by Alliance of Genome Resources, Apr 2022]

Unc13a Products(1)

mRNA	Protein	Name
NM_001029873.2	NP_001025044.2	protein unc-13 homolog A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calmodulin binding	IDA IDA: Inferred from direct assay	31787876	MGI
enables diacylglycerol binding	IDA IDA: Inferred from direct assay	15123597	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	10488064	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within amyloid-beta metabolic process	IMP IMP: Inferred from mutant phenotype	15123597	MGI
NOT involved in dense core granule docking	IGI IGI: Inferred from genetic interaction	26575293	MGI
acts upstream of or within innervation	IGI IGI: Inferred from genetic interaction	15988013	MGI
acts upstream of or within neuromuscular junction development	IGI IGI: Inferred from genetic interaction	15988013	MGI
involved in neuronal dense core vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	23229896	MGI
acts upstream of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	11792326	MGI
involved in positive regulation of glutamate receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	23070049	MGI
acts upstream of or within positive regulation of neurotransmitter secretion	IMP IMP: Inferred from mutant phenotype	11792326	MGI
involved in positive regulation of synaptic plasticity	IGI IGI: Inferred from genetic interaction	23658173	MGI
involved in regulation of amyloid precursor protein catabolic process	IMP IMP: Inferred from mutant phenotype	23070049	MGI
acts upstream of or within regulation of short-term neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	11832228	MGI
acts upstream of or within synaptic transmission, glutamatergic	IGI IGI: Inferred from genetic interaction	11792326	MGI
acts upstream of or within synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	11832228	MGI
acts upstream of or within synaptic vesicle docking	IGI IGI: Inferred from genetic interaction	19558619	MGI
involved in synaptic vesicle exocytosis	IDA IDA: Inferred from direct assay	10440375	MGI
involved in synaptic vesicle exocytosis	IMP IMP: Inferred from mutant phenotype	10440375	MGI
acts upstream of or within synaptic vesicle maturation	IMP IMP: Inferred from mutant phenotype	10440375	MGI
involved in synaptic vesicle priming	IMP IMP: Inferred from mutant phenotype	11832228	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	23791195	MGI
is active in calyx of Held	IDA IDA: Inferred from direct assay	23658173	MGI
located in calyx of Held	IDA IDA: Inferred from direct assay	23658173	MGI
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	10440375	MGI
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	10440375	MGI
located in neuromuscular junction	IDA IDA: Inferred from direct assay	15988013	MGI
located in presynapse	IDA IDA: Inferred from direct assay	25609709	MGI
is active in presynaptic active zone	IDA IDA: Inferred from direct assay	23658173	MGI
located in presynaptic active zone	IDA IDA: Inferred from direct assay	23658173	MGI
located in synapse	IDA IDA: Inferred from direct assay	23791195	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein unc-13 homolog A

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15464	UNC13A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21216	Unc13a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Unc13a	NCBI	NCBI:23025

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