2. Gene
  3. Tp73 - tumor protein p73 Gene

Tp73 - tumor protein p73 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as P73; Trp73

Gene ID: 362675 | Gene type: protein coding

About Tp73

Summary

Enables sequence-specific DNA binding activity. Involved in several processes, including negative regulation of neuron differentiation; positive regulation of MAPK cascade; and positive regulation of oligodendrocyte differentiation. Located in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in breast cancer; lung cancer; nephroblastoma; primary ciliary dyskinesia; and renal cell carcinoma. Orthologous to human TP73 (tumor protein p73). [provided by Alliance of Genome Resources, Apr 2022]

Tp73 Products(1)

mRNA Protein Name
NM_001108696.1 NP_001102166.1 tumor protein p73
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables sequence-specific DNA binding IDA
IDA: Inferred from direct assay
15805112 RGD
Biological Process GO Annotation Evidence Reference Source
involved in kidney development IEP
IEP: Inferred from expression pattern
15805112 RGD
involved in negative regulation of neuron differentiation IMP
IMP: Inferred from mutant phenotype
17353261 RGD
involved in positive regulation of MAPK cascade IMP
IMP: Inferred from mutant phenotype
17353261 RGD
involved in positive regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
15716325 RGD
involved in positive regulation of oligodendrocyte differentiation IMP
IMP: Inferred from mutant phenotype
14960496 RGD
involved in response to xenobiotic stimulus IEP
IEP: Inferred from expression pattern
20519366 RGD
Cellular Component GO Annotation Evidence Reference Source
located in chromatin IDA
IDA: Inferred from direct assay
15805112 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

tumor protein p73

transformation related protein 73

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14924 TP73 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26467 Tp73 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Tp73 NCBI NCBI:7161