IGKC - immunoglobulin kappa constant Gene

Homo sapiens

Also known as Km; HCAK1; IGKCD

Gene ID: 3514 | Gene type: other

About IGKC

Cytogenetic location: 2p11.2 Genomic coordinates (GRCh38): 2:88,857,361-88,857,683 (from NCBI)

This gene has 1 transcript (splice variant), 100 orthologues, 82 paralogues and is associated with 1 phenotype.

Summary

Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Involved in retina homeostasis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in adaptive immune response	IDA IDA: Inferred from direct assay	11498595	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of IgG immunoglobulin complex	IPI IPI: Inferred from physical interaction	11498595	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGKC Protein Structure

C1-set

0
100
107 a.a.

IGKC Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82251	Human kappa Light Chain Antibody (YA1996)	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases

Alias

Immunoglobulin Kappa Light Chain Deficiency

Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency	IGKCD
Kappa Chain Deficiency	Kappa Light Chain Deficiency
Kappa-Chain Deficiency	Igg Subclass Deficiency With Iga Subclass Deficiency
Isolated Igg Subclass Deficiency	Selective Igg Subclass Deficiency

Amyloidosis

Amyloid Disease	Amyloid
Amyloid Degeneration	Amyloidosis Nos
Amyloid Deposition	Amyloid Infiltration
Idiopathic Amyloidosis	Hyaloid Degeneration
Lardaceous Degeneration

Plasmacytoma

Solitary Plasmacytoma	Solitary Myeloma
Myeloma - Solitary	Myeloma, Solitary
Plasmacytoma - Category	Solitary Osseous Plasmacytoma
Solitary Plasmacytoma Without Mention Of Remission	Localised Malignant Plasma Cell Tumour Nos
Plasmacytoma Nos

Lymphoma, Mucosa-Associated Lymphoid Type

Malt Lymphoma	Gastric Lymphoma, Primary
Lymphoma, Malt, Somatic	Mucosa-Associated Lymphoid Tissue Lymphoma
Extranodal Marginal Zone B-Cell Lymphoma	MALTOMA
Marginal Zone B-Cell Lymphoma	Mucosa-Associated Lymphatic Tissue Lymphoma
Primary Gastric Lymphoma	Gastric Lymphoma
Familial Primary Gastric Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-171199	In vivo Igkc Mouse Pre-designed siRNA-1	Pre-designed Sets	/	Unkown
HY-171200	In vivo Igkc Mouse Pre-designed siRNA-2	Pre-designed Sets	/	Unkown
HY-171201	In vivo Igkc Mouse Pre-designed siRNA-3	Pre-designed Sets	/	Unkown
HY-RS16350	IGKC Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19105	Igkc Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25253	Igkc Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IGKC	RGD	RGD:1562743

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