IGHA1 - immunoglobulin heavy constant alpha 1 Gene

Homo sapiens

Also known as IgA1

Gene ID: 3493 | Gene type: other

About IGHA1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:105,707,168-105,708,664 (from NCBI)

This gene has 2 transcripts (splice variants), 1 gene allele, 87 orthologues and 82 paralogues.

Summary

Contributes to immunoglobulin receptor binding activity. Involved in Antibacterial humoral response; glomerular filtration; and positive regulation of respiratory burst. Located in extracellular space. Part of monomeric IgA immunoglobulin complex and secretory dimeric IgA immunoglobulin complex. [provided by Alliance of Genome Resources, Apr 2022]

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
contributes to immunoglobulin receptor binding	IDA IDA: Inferred from direct assay	23250751	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antibacterial humoral response	IDA IDA: Inferred from direct assay	23250751	GOA
involved in glomerular filtration	IMP IMP: Inferred from mutant phenotype	23398317	GOA
involved in positive regulation of respiratory burst	IDA IDA: Inferred from direct assay	24145934	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	23398317	GOA
part of monomeric IgA immunoglobulin complex	IDA IDA: Inferred from direct assay	23250751	GOA
part of secretory IgA immunoglobulin complex	IDA IDA: Inferred from direct assay	23250751	GOA
part of secretory dimeric IgA immunoglobulin complex	IDA IDA: Inferred from direct assay	24145934	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IGHA1 Protein Structure

C1-set

Ig_2

C1-set

0
100
200
300
353 a.a.

IGHA1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83914	IghA1 Antibody (YA3611)	WB, IHC-P, ICC/IF, FC, ELISA	Human, Mouse, Monkey

Related Diseases

Diseases

Alias

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	IGHA1	MGD	MGI:96444

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