2. Gene
  3. Hcn4 - hyperpolarization-activated, cyclic nucleotide-gated K+ 4 Gene

Hcn4 - hyperpolarization-activated, cyclic nucleotide-gated K+ 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Hcn3; Bcng3

Gene ID: 330953 | Gene type: protein coding

About Hcn4

Summary

Enables intracellular cAMP-activated cation channel activity. Acts upstream of or within cation transport; in utero embryonic development; and regulation of heart contraction. Located in axon. Is expressed in eye; future brain; heart; septum transversum; and venous system. Human ortholog(s) of this gene implicated in Brugada syndrome 8; Gilles de la Tourette syndrome; idiopathic generalized epilepsy; and sick sinus syndrome. Orthologous to human HCN4 (hyperpolarization activated cyclic nucleotide gated Potassium Channel 4). [provided by Alliance of Genome Resources, Apr 2022]

Hcn4 Products(1)

mRNA Protein Name
NM_001081192.3 NP_001074661.1 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables intracellularly cAMP-activated cation channel activity IMP
IMP: Inferred from mutant phenotype
14657344 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
15564593 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within in utero embryonic development IMP
IMP: Inferred from mutant phenotype
14657344 MGI
acts upstream of or within monoatomic cation transport IMP
IMP: Inferred from mutant phenotype
14657344 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
14657344 MGI
Cellular Component GO Annotation Evidence Reference Source
located in axon IDA
IDA: Inferred from direct assay
23172916 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4

brain cyclic nucleotide-gated channel 3

hyperpolarization-activated, cyclic nucleotide-gated K+ 3

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-18940 Cilobradine / Phase 2
Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13422 Zatebradine hydrochloride Antagonist 99.87% Unkown
HY-13422A Zatebradine Antagonist 99.27% Unkown
HY-160505 RO-275 Inhibitor ≥99.0% Unkown
HY-119102 BPU-11 98.08% Unkown
HY-RS06049 HCN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19140 Hcn3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20286 Hcn4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26794 Hcn4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hcn4 NCBI NCBI:10021