Itpkb - inositol 1,4,5-trisphosphate 3-kinase B Gene

Mus musculus

Also known as 1110033J02Rik; E130307H12Rik

Gene ID: 320404 | Gene type: protein coding

About Itpkb

Summary

Enables inositol-1,4,5-trisphosphate 3-kinase activity. Acts upstream of or within several processes, including common myeloid progenitor cell proliferation; negative regulation of neutrophil apoptotic process; and regulation of hemopoiesis. Located in cytosol; membrane; and nucleus. Is expressed in alimentary system; facial bone primordium; liver; nervous system; and urinary system. Orthologous to human ITPKB (inositol-trisphosphate 3-kinase B). [provided by Alliance of Genome Resources, Apr 2022]

Itpkb Products(1)

mRNA	Protein	Name
NM_001081175.1	NP_001074644.1	inositol-trisphosphate 3-kinase B

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables inositol-1,4,5-trisphosphate 3-kinase activity	IDA IDA: Inferred from direct assay	14517551	MGI
enables inositol-1,4,5-trisphosphate 3-kinase activity	IMP IMP: Inferred from mutant phenotype	15064401	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within MAPK cascade	IMP IMP: Inferred from mutant phenotype	15064401	MGI
acts upstream of or within T cell differentiation	IMP IMP: Inferred from mutant phenotype	14517551	MGI
acts upstream of or within cell surface receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15064401	MGI
acts upstream of or within common myeloid progenitor cell proliferation	IMP IMP: Inferred from mutant phenotype	18339802	MGI
acts upstream of or within myeloid cell homeostasis	IMP IMP: Inferred from mutant phenotype	18339802	MGI
acts upstream of or within negative regulation of myeloid cell differentiation	IMP IMP: Inferred from mutant phenotype	18339802	MGI
acts upstream of or within negative regulation of neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	18339802	MGI
acts upstream of or within positive regulation of Ras protein signal transduction	IMP IMP: Inferred from mutant phenotype	15064401	MGI
acts upstream of or within positive regulation of alpha-beta T cell differentiation	IMP IMP: Inferred from mutant phenotype	15064401	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: Inferred from mutant phenotype	15064401	MGI
acts upstream of or within regulation of protein phosphorylation	IMP IMP: Inferred from mutant phenotype	18339802	MGI
acts upstream of or within thymic T cell selection	IMP IMP: Inferred from mutant phenotype	14517551	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytosol	IDA IDA: Inferred from direct assay	15381088	MGI
located in membrane	IDA IDA: Inferred from direct assay	15381088	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15381088	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

inositol-trisphosphate 3-kinase B

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126750	GNF362	Inhibitor	99.86%	Unkown
HY-RS06989	ITPKB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19451	Itpkb Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25943	Itpkb Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itpkb	NCBI	NCBI:3707

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