Cd2ap - CD2-associated protein Gene

Rattus norvegicus

Also known as CMS

Gene ID: 316258 | Gene type: protein coding

About Cd2ap

Summary

Enables several functions, including beta-catenin binding activity; Cadherin binding activity; and protein C-terminus binding activity. Involved in several processes, including cell-cell adhesion; proteasome-mediated ubiquitin-dependent protein catabolic process; and regulation of receptor-mediated endocytosis. Located in cell leading edge; endocytic vesicle; and perinuclear region of cytoplasm. Part of protein-containing complex. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis and focal segmental glomerulosclerosis 3. Orthologous to human CD2AP (CD2 associated protein). [provided by Alliance of Genome Resources, Apr 2022]

Cd2ap Products(1)

mRNA	Protein	Name
NM_181475.3	NP_852140.2	CD2-associated protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables beta-catenin binding	IDA IDA: Inferred from direct assay	16617054	RGD
enables cadherin binding	IPI IPI: Inferred from physical interaction	15910750	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15001553	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	16617054	RGD
enables vascular endothelial growth factor receptor binding	IDA IDA: Inferred from direct assay	15001553	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cell migration	IMP IMP: Inferred from mutant phenotype	15910750	RGD
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	16617054	RGD
involved in proteasome-mediated ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	15001553	RGD
involved in regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	15001553	RGD
involved in vesicle organization	IDA IDA: Inferred from direct assay	15001553	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell leading edge	IDA IDA: Inferred from direct assay	15910750	RGD
located in endocytic vesicle	IDA IDA: Inferred from direct assay	15001553	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	15910750	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	16617054	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CD2-associated protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS21509	Cd2ap Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02224	CD2AP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28027	Cd2ap Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd2ap	NCBI	NCBI:23607

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