2. Gene
  3. Pml - PML nuclear body scaffold Gene

Pml - PML nuclear body scaffold Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1562602

Gene ID: 315713 | Gene type: protein coding

About Pml

Summary

Predicted to enable several functions, including protein dimerization activity; transition metal ion binding activity; and ubiquitin-like protein transferase activity. Predicted to be involved in several processes, including regulation of cellular protein metabolic process; regulation of nucleobase-containing compound metabolic process; and signal transduction by p53 class mediator. Predicted to act upstream of or within several processes, including apoptotic signaling pathway; positive regulation of macromolecule metabolic process; and protein localization to nucleus. Predicted to be located in chromosome, telomeric region; cytosol; and nucleus. Predicted to be extrinsic component of endoplasmic reticulum membrane. Predicted to be active in PML body and chromatin. Predicted to colocalize with heterochromatin. Human ortholog(s) of this gene implicated in acute promyelocytic leukemia and skin Cancer. Orthologous to human PML (PML nuclear body scaffold). [provided by Alliance of Genome Resources, Apr 2022]

Pml Products(3)

mRNA Protein Name
XM_039082399.1 XP_038938327.1 protein PML isoform X1
XM_039082400.1 XP_038938328.1 protein PML isoform X1
XM_039082401.1 XP_038938329.1 protein PML isoform X2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
20639899 RGD
Biological Process GO Annotation Evidence Reference Source
involved in PML body organization IMP
IMP: Inferred from mutant phenotype
17289031 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein PML

promyelocytic leukemia

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N10633 LSTc 99.64% Unkown
HY-127130 Spicamycin / Unkown
HY-RS10765 PML Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18592 Pml Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25077 Pml Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pml NCBI NCBI:5371