Rdx - radixin Gene

Rattus norvegicus

Gene ID: 315655 | Gene type: protein coding

About Rdx

Summary

Enables actin binding activity. Involved in apical protein localization; barbed-end actin filament capping; and cellular response to platelet-derived growth factor stimulus. Located in several cellular components, including T-tubule; cleavage furrow; and midbody. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 24. Orthologous to human RDX (radixin). [provided by Alliance of Genome Resources, Apr 2022]

Rdx Products(1)

mRNA	Protein	Name
NM_001005889.2	NP_001005889.2	radixin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IDA IDA: Inferred from direct assay	2500445	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	7844168	RGD
enables protein kinase A binding	IMP IMP: Inferred from mutant phenotype	21047789	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in apical protein localization	IMP IMP: Inferred from mutant phenotype	16952556	RGD
involved in barbed-end actin filament capping	IDA IDA: Inferred from direct assay	2500445	RGD
involved in cellular response to platelet-derived growth factor stimulus	IEP IEP: Inferred from expression pattern	8647942	RGD
involved in cellular response to thyroid hormone stimulus	IMP IMP: Inferred from mutant phenotype	21047789	RGD
involved in establishment of protein localization to plasma membrane	IMP IMP: Inferred from mutant phenotype	21047789	RGD
involved in positive regulation of G1/S transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	21047789	RGD
involved in protein kinase A signaling	IMP IMP: Inferred from mutant phenotype	21047789	RGD
involved in regulation of Rap protein signal transduction	IMP IMP: Inferred from mutant phenotype	21047789	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	19028724	RGD
located in adherens junction	IDA IDA: Inferred from direct assay	2500445	RGD
located in cell tip	IDA IDA: Inferred from direct assay	17061246	RGD
located in cleavage furrow	IDA IDA: Inferred from direct assay	1707055	RGD
located in cortical actin cytoskeleton	IDA IDA: Inferred from direct assay	21047789	RGD
located in filopodium	IDA IDA: Inferred from direct assay	21047789	RGD
located in lamellipodium	IDA IDA: Inferred from direct assay	21047789	RGD
located in microvillus	IDA IDA: Inferred from direct assay	11438984	RGD
located in midbody	IDA IDA: Inferred from direct assay	1707055	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21047789	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

radixin

Related Agents

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15991	Tenapanor	Inhibitor	99.65%	Unkown
HY-15991A	Tenapanor hydrochloride	Inhibitor	99.55%	Unkown

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13631J	(1R,9R)-Exatecan mesylate		99.94%	Unkown
HY-13631I	(1S,9R)-Exatecan mesylate		98.23%	Unkown
HY-P2800	Diaphorase, Recombinant microorganisms		/	Unkown
HY-RS11806	RDX Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18121	Rdx Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24595	Rdx Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rdx	NCBI	NCBI:5962
Mus musculus	Rdx	NCBI	NCBI:19684

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