Abca1 - ATP binding cassette subfamily A member 1 Gene

Rattus norvegicus

Gene ID: 313210 | Gene type: protein coding

About Abca1

Summary

Enables ATPase-coupled transmembrane transporter activity and high-density lipoprotein particle binding activity. Involved in several processes, including cellular response to cholesterol; lipid transport; and lipoprotein biosynthetic process. Located in basolateral plasma membrane and cell surface. Biomarker of several diseases, including extrahepatic cholestasis; fatty liver disease; membranous glomerulonephritis; obesity; and premature menopause. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hypolipoproteinemia (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human ABCA1 (ATP binding cassette subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Abca1 Products(1)

mRNA	Protein	Name
NM_178095.3	NP_835196.2	phospholipid-transporting ATPase ABCA1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase-coupled transmembrane transporter activity	IDA IDA: Inferred from direct assay	12909583	RGD
enables high-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	15907796	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cholesterol	IEP IEP: Inferred from expression pattern	15907796	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	25445438	RGD
involved in cellular response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	21554872	RGD
involved in cholesterol transport	IDA IDA: Inferred from direct assay	12909583	RGD
involved in cholesterol transport	IMP IMP: Inferred from mutant phenotype	14993246	RGD
involved in lipoprotein biosynthetic process	IEP IEP: Inferred from expression pattern	21554872	RGD
involved in lipoprotein biosynthetic process	IMP IMP: Inferred from mutant phenotype	14993246	RGD
involved in phospholipid transport	IDA IDA: Inferred from direct assay	12909583	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15710224	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25612518	RGD
involved in response to vitamin B3	IEP IEP: Inferred from expression pattern	19878707	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	14690017	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	28660384	RGD
located in cell surface	IDA IDA: Inferred from direct assay	15907796	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

phospholipid-transporting ATPase ABCA1

ATP-binding cassette sub-family A member 1	ATP-binding cassette, sub-family A (ABC1), member 1
ATP-binding cassette, subfamily A (ABC1), member 1

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0388	Probucol		99.97%	Yes

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-134377	Bocidelpar	Modulator	98.08%	Phase 2
HY-P6306A	CS-6253 TFA		98.53%	Phase 1

Pre-clinical Phase

Bioactive Molecules (23)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-D0086	DIDS sodium salt	Inhibitor	99.13%	Unkown
HY-18282	AZ876	Agonist	99.77%	Unkown
HY-123402	GSK3987	Agonist	99.19%	Unkown
HY-N2419	Erythrodiol		99.75%	Unkown
HY-N0686	Pseudoprotodioscin	Inhibitor	98.76%	Unkown
HY-P6306	CS-6253		98.84%	Unkown
HY-123148	IMB-808	Agonist	99.85%	Unkown
HY-117006	E1231	Activator	98.55%	Unkown
HY-141645	IMM-H007		97.07%	Unkown
HY-N0364	Falcarindiol		99.48%	Unkown
HY-143200	OSBPL7-IN-1	Inhibitor	99.79%	Unkown
HY-122936	Tanshindiol C		98.47%	Unkown
HY-RS00037	ABCA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-121671	TBTC	Activator	/	Unkown
HY-121693	DIDS	Inhibitor	/	Unkown
HY-169080	ABCA1 inducer 1	Inducer	/	Unkown
HY-170570	PFM046		/	Unkown
HY-173230	ABCA1 inducer 2		/	Unkown
HY-N13361	Elodeoidileon A	Agonist	/	Unkown
HY-W201317	E17241	Agonist	/	Unkown
HY-RS16554	Abca1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22987	Abca1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W590664	C2 Dihydroceramide		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abca1	NCBI	NCBI:19

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