2. Gene
  3. CYLD - Cyld CYLD lysine 63 deubiquitinase Gene

CYLD - Cyld CYLD lysine 63 deubiquitinase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Rp1; Rp1h; LRRGT00003

Gene ID: 312937 | Gene type: protein coding

About CYLD

Summary

Predicted to enable several functions, including Deubiquitinase activity; proline-rich region binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including protein deubiquitination; regulation of organelle organization; and regulation of signal transduction. Predicted to act upstream of or within several processes, including positive regulation of T cell receptor signaling pathway; regulation of lymphocyte differentiation; and ripoptosome assembly involved in necroptotic process. Predicted to be located in ciliary tip and microtubule Cytoskeleton. Predicted to be extrinsic component of cytoplasmic side of plasma membrane. Predicted to be part of cytosolic small ribosomal subunit. Predicted to be active in cytosol. Predicted to colocalize with cytoplasmic microtubule and midbody. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 Deubiquitinase). [provided by Alliance of Genome Resources, Apr 2022]

CYLD Products(1)

mRNA Protein Name
NM_001017380.1 NP_001017380.1 ubiquitin carboxyl-terminal hydrolase CYLD
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: Inferred from direct assay
28973854 RGD
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IMP
IMP: Inferred from mutant phenotype
28973854 RGD
involved in regulation protein catabolic process at postsynapse IDA
IDA: Inferred from direct assay
28973854 RGD
involved in regulation protein catabolic process at postsynapse IEP
IEP: Inferred from expression pattern
28973854 RGD
involved in regulation protein catabolic process at postsynapse IMP
IMP: Inferred from mutant phenotype
28973854 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
24614225 RGD
is active in glutamatergic synapse IMP
IMP: Inferred from mutant phenotype
28973854 RGD
is active in postsynaptic density IDA
IDA: Inferred from direct assay
24614225 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase CYLD

40S ribosomal protein S3a-like

cylindromatosis (turban tumor syndrome)

deubiquitinating enzyme CYLD

probable ubiquitin carboxyl-terminal hydrolase CYLD

probable ubiquitin carboxyl-terminal hydrolase CYLD-like

retinitis pigmentosa 1 homolog

ubiquitin

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-176426 Subquinocin / Phase 4
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03433 CYLD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17882 Cyld Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS24351 Cyld Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens CYLD NCBI NCBI:1540