Trpa1 - transient receptor potential cation channel, subfamily A, member 1 Gene

Rattus norvegicus

Also known as Anktm1

Gene ID: 312896 | Gene type: protein coding

About Trpa1

Summary

Enables osmolarity-sensing cation channel activity and voltage-gated Calcium Channel activity. Involved in several processes, including cellular response to caffeine; positive regulation of transport; and regulation of nervous system process. Located in apical plasma membrane and axon. Used to study asthma and diabetic neuropathy. Human ortholog(s) of this gene implicated in familial episodic pain syndrome 1. Orthologous to human TRPA1 (transient receptor potential cation channel subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Trpa1 Products(1)

mRNA	Protein	Name
NM_207608.2	NP_997491.2	transient receptor potential cation channel subfamily A member 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables osmolarity-sensing monoatomic cation channel activity	IDA IDA: Inferred from direct assay	18279313	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20231274	RGD
enables voltage-gated calcium channel activity	IDA IDA: Inferred from direct assay	14712238	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in calcium ion transmembrane import into cytosol	IDA IDA: Inferred from direct assay	14712238	RGD
involved in calcium ion transmembrane import into cytosol	IMP IMP: Inferred from mutant phenotype	31969645	RGD
involved in cellular response to caffeine	IEP IEP: Inferred from expression pattern	22319196	RGD
involved in cellular response to carbon dioxide	IDA IDA: Inferred from direct assay	20881114	RGD
involved in cellular response to cold	IMP IMP: Inferred from mutant phenotype	21068322	RGD
involved in cellular response to heat	IMP IMP: Inferred from mutant phenotype	22458587	RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP IMP: Inferred from mutant phenotype	22701540	RGD
involved in positive regulation of monoatomic anion transport	IMP IMP: Inferred from mutant phenotype	22207576	RGD
involved in regulation of blood circulation	IMP IMP: Inferred from mutant phenotype	22133672	RGD
involved in regulation of neuronal action potential	IMP IMP: Inferred from mutant phenotype	20205719	RGD
involved in urinary bladder smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	21367919	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	22207576	RGD
located in axon	IDA IDA: Inferred from direct assay	18514429	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transient receptor potential cation channel subfamily A member 1

ankyrin-like with transmembrane domains protein 1

wasabi receptor

Related Agents

Approval

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N6810	Thymol		99.97%	Yes
HY-B1173	(+)-Camphor	Inhibitor	≥98.0%	Unkown
HY-N6810R	Thymol (Standard)		/	Unkown

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-108463	A-967079	Antagonist	99.30%	Phase 1
HY-115877	GDC-0334	Antagonist	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (56)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-100965	Diphenyleneiodonium chloride		99.91%	Unkown
HY-15064	HC-030031	Inhibitor	99.49%	Unkown
HY-153169	6PPD-Q	Inhibitor	99.30%	Unkown
HY-101507	Zerencotrep	Inhibitor	99.47%	Unkown
HY-N6825	Hydroxy-α-sanshool	Agonist	99.57%	Unkown
HY-107436	LE135		≥99.0%	Unkown
HY-111132	JT010	Agonist	99.48%	Unkown
HY-135013	Umbellulone	Activator	99.60%	Unkown
HY-18662	RQ-00203078	Antagonist	99.84%	Unkown
HY-N8264	Moringin	Agonist	99.95%	Unkown
HY-18779	PF-4840154	Agonist	98.15%	Unkown
HY-108329	AM-0902	Antagonist	99.73%	Unkown
HY-101907	ASP7663	Agonist	99.16%	Unkown
HY-W014421	AP-18	Inhibitor	99.61%	Unkown
HY-120689	PF-04745637	Antagonist	99.97%	Unkown
HY-121539	Supercinnamaldehyde	Activator	≥99.0%	Unkown
HY-121636	Resolvin D2	Inhibitor	99.90%	Unkown
HY-W002116	Methyl syringate		99.96%	Unkown
HY-148236	BAY-390	Inhibitor	99.74%	Unkown
HY-156684	Nedizantrep	Inhibitor	99.77%	Unkown
HY-N2318	Podocarpic acid	Agonist	99.78%	Unkown
HY-12809	Optovin	Activator	99.81%	Unkown
HY-107535	AS1269574		99.84%	Unkown
HY-15065	Chembridge-5861528	Antagonist	99.12%	Unkown
HY-134098	Diisopropyl adipate	Activator	99.90%	Unkown
HY-153711	TRPA1-IN-2	Inhibitor	99.82%	Unkown
HY-N7117	1,4-Cineole	Activator	≥95.0%	Unkown
HY-114524	(E)-4-Oxo-2-nonenal	Agonist	≥95.0%	Unkown
HY-P5914A	Wasabi Receptor Toxin TFA	Activator	99.49%	Unkown
HY-N10319	Artepillin C		95.91%	Unkown
HY-121636S	Resolvin D2-d5	Inhibitor	≥99.0%	Unkown
HY-N7536	Voacangine		98.78%	Unkown
HY-P5914	Wasabi Receptor Toxin	Activator	/	Unkown
HY-W008356	2-Fluoro-4-iodobenzonitrile		/	Unkown
HY-W106234	4-(Phenyldiazenyl)benzoic acid	Agonist	98.81%	Unkown
HY-142214	TRPA1-IN-1	Antagonist	/	Unkown
HY-111494	TRPA1 Antagonist 1	Inhibitor	/	Unkown
HY-104061	AMG8788	Antagonist	/	Unkown
HY-104062	AMG9678	Antagonist	/	Unkown
HY-139904	TRPA1 Antagonist 3	Agonist	/	Unkown
HY-15056	AMG 9090	Agonist	/	Unkown
HY-170652	ZQMT-10	Inhibitor	/	Unkown
HY-172898	TRPA1-IN-4	Inhibitor	/	Unkown
HY-173471	TRPA1 agonist-1	Agonist	/	Unkown
HY-N12605	hTRPA1-IN-1	Inhibitor	/	Unkown
HY-N7965	Methyl kakuol	Agonist	/	Unkown
HY-P10356	T100-Mut	Inhibitor	/	Unkown
HY-RS15103	TRPA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W002116S	Methyl syringate-d6		/	Unkown
HY-W010270A	Aurothiomalate disodium		/	Unkown
HY-113018	Ibuprofen acyl-β-D-glucuronide	Antagonist	/	Unkown
HY-159134	TRPA1-IN-3	Inhibitor	99.66%	Unkown
HY-N10612	Petasin		/	Unkown
HY-RS16515	Trpa1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS22946	Trpa1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W708469	Resolvin D2 methyl ester	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Trpa1	NCBI	NCBI:8989

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