Ror2 - receptor tyrosine kinase-like orphan receptor 2 Gene

Rattus norvegicus

Gene ID: 306782 | Gene type: protein coding

About Ror2

Summary

Predicted to enable several functions, including Wnt-protein binding activity; Frizzled binding activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including positive regulation of glutamatergic synaptic transmission; positive regulation of macrophage differentiation; and positive regulation of protein serine/threonine kinase activity. Located in several cellular components, including dendrite; microtubule; and neuronal cell body. Human ortholog(s) of this gene implicated in autosomal recessive Robinow syndrome; brachydactyly type B1; and cleft palate. Orthologous to human ROR2 (receptor tyrosine kinase like Orphan Receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Ror2 Products(1)

mRNA	Protein	Name
NM_001107339.1	NP_001100809.1	tyrosine-protein kinase transmembrane receptor ROR2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in astrocyte development	IDA IDA: Inferred from direct assay	15095375	RGD
involved in bone mineralization	IEP IEP: Inferred from expression pattern	23337931	RGD
involved in macrophage migration	IMP IMP: Inferred from mutant phenotype	25749876	RGD
involved in male genitalia development	IEP IEP: Inferred from expression pattern	23895974	RGD
involved in modulation of chemical synaptic transmission	IDA IDA: Inferred from direct assay	26311509	RGD
involved in modulation of chemical synaptic transmission	IMP IMP: Inferred from mutant phenotype	26311509	RGD
involved in positive regulation of JUN kinase activity	IMP IMP: Inferred from mutant phenotype	25825749	RGD
involved in positive regulation of macrophage differentiation	IMP IMP: Inferred from mutant phenotype	25749876	RGD
involved in positive regulation of protein kinase C activity	IMP IMP: Inferred from mutant phenotype	25825749	RGD
involved in positive regulation of synaptic transmission, glutamatergic	IMP IMP: Inferred from mutant phenotype	25825749	RGD
involved in regulation of postsynapse organization	IDA IDA: Inferred from direct assay	26003414	RGD
involved in regulation of postsynapse organization	IMP IMP: Inferred from mutant phenotype	26003414	RGD
involved in regulation of synaptic signaling by nitric oxide	IDA IDA: Inferred from direct assay	26311509	RGD
involved in regulation of synaptic signaling by nitric oxide	IMP IMP: Inferred from mutant phenotype	26311509	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	15095375	RGD
located in dendrite	IDA IDA: Inferred from direct assay	25825749	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	26003414	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	26003414	RGD
located in microtubule	IDA IDA: Inferred from direct assay	15095375	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	25825749	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	26003414	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

tyrosine-protein kinase transmembrane receptor ROR2

Related Agents

Clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-145626	Ozuriftamab		99.73%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12125	ROR2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17495	Ror2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23952	Ror2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-145627	Ozuriftamab vedotin	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ror2	NCBI	NCBI:4920
Macaca fascicularis	Ror2	NCBI	NCBI:102118636

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