2. Gene
  3. Pole - DNA polymerase epsilon, catalytic subunit Gene

Pole - DNA polymerase epsilon, catalytic subunit Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as POLE1

Gene ID: 304573 | Gene type: protein coding

About Pole

Summary

Enables DNA-directed DNA Polymerase activity. Involved in DNA biosynthetic process and embryonic organ development. Predicted to be located in nucleoplasm and plasma membrane. Predicted to be part of epsilon DNA Polymerase complex. Human ortholog(s) of this gene implicated in colorectal Cancer. Orthologous to human POLE (DNA Polymerase epsilon, catalytic subunit). [provided by Alliance of Genome Resources, Apr 2022]

Pole Products(1)

mRNA Protein Name
NM_001107152.2 NP_001100622.2 DNA polymerase epsilon catalytic subunit A
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables DNA-directed DNA polymerase activity IMP
IMP: Inferred from mutant phenotype
11959615 RGD
Biological Process GO Annotation Evidence Reference Source
involved in DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
11959615 RGD
involved in embryonic organ development IEP
IEP: Inferred from expression pattern
11425516 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DNA polymerase epsilon catalytic subunit A

DNA-directed DNA polymerase epsilon

polymerase (DNA directed), epsilon, catalytic subunit

polymerase (DNA) epsilon, catalytic subunit

Related Agents

Pre-clinical Phase
Bioactive Molecules (11)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153066 VLS-1272 98.09% Unkown
HY-121908 FCPT Inhibitor / Unkown
HY-RS10825 POLE Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10826 POLE2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10827 POLE3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS10828 POLE4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-B0824A (1R)-cis-Bifenthrin / Unkown
HY-RS17692 Pole Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22734 Pole2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24154 Pole Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29248 Pole2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pole NCBI NCBI:5426
Mus musculus Pole NCBI NCBI:18973